MINI REVIEW article
Front. Pharmacol.
Sec. Pharmacogenetics and Pharmacogenomics
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1621163
This article is part of the Research TopicPharmacoepigenetics in Personalized MedicineView all articles
Statins and their impact on epigenetic regulation: insights into disease
Provisionally accepted
Rafael Tamayo-Trujillo
Patricia Guevara-Ramírez
Santiago Cadena-Ullauri
Viviana A. Ruiz-Pozo
Elius Andrés Paz Cruz
Ana Karina Zambrano*- Centro de Investigación Genética y Genómica, Facultad de Ciencias de la Salud Eugenio Espejo, Universidad UTE, Quito, Ecuador, Quito, Ecuador
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Statins have been primarily used for the management of low-density lipoprotein (LDL) cholesterol and cardiovascular diseases (CVD). However, in recent years, research has identified potential applications beyond cholesterol regulation. Statins exhibit pleiotropic effects, due to their ability to modulate gene expression via epigenetic mechanisms, including DNA methylation, histone acetylation, and microRNA regulation. Clinical studies have correlated these epigenetic changes with various pathological conditions, such as inflammation, atherosclerosis, cancer, diabetes, and autoimmune disorders. Despite encouraging findings, further research is required to fully understand the molecular pathways associated with the epigenetic actions of statins and disease pathogenesis. This review describes the potential role of statins as epigenetic modulators and their relevance in human disease management.
Keywords: Pharmacology, Pharmacoepigenetics, epigenetics, Statins, Molecular Biology
Received: 30 Apr 2025; Accepted: 04 Jul 2025.
Copyright: © 2025 Tamayo-Trujillo, Guevara-Ramírez, Cadena-Ullauri, Ruiz-Pozo, Paz Cruz and Zambrano. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ana Karina Zambrano, Centro de Investigación Genética y Genómica, Facultad de Ciencias de la Salud Eugenio Espejo, Universidad UTE, Quito, Ecuador, Quito, Ecuador
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