REVIEW article
Front. Pharmacol.
Sec. Renal Pharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1625139
Post-Translational Modifications in Sepsis-Induced Acute Kidney Injury: Mechanisms and Perspectives
Provisionally accepted
- 1Department of Intensive Care Medicine, Northern Jiangsu People's Hospital, Yangzhou, China
- 2Yangzhou University Hospital, Yangzhou, China
- 3Shandong First Medical university, Shandong, China
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Sepsis-induced acute kidney injury (SA-AKI), a grave clinical issue with a high mortality rate, has impacted millions of individuals worldwide. Sepsis is a syndrome characterized by life-threatening organ dysfunction resulting from a dysregulated host response to infection. Post-translational modifications (PTMs) refer to the chemical alterations that proteins undergo after their synthesis is complete. Various types of PTMs, including phosphorylation, methylation, acetylation, lactylation, and ubiquitination, may play a crucial role in the acute kidney injury (AKI) associated with sepsis by modulating protein function, stability, and interactions. This article highlights the advances in understanding the role of PTMs in the pathogenesis of sepsis-induced acute kidney injury (SA-AKI), addressing existing challenges and offering future perspectives.
Keywords: Acute Kidney Injury, Sepsis, post-translational modifications, Sepsis-induced acute kidney injury, Inflammation
Received: 15 May 2025; Accepted: 12 Aug 2025.
Copyright: © 2025 Zheng, Song, Jiang, Liu, Wang, Gong and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ruiqiang Zheng, Department of Intensive Care Medicine, Northern Jiangsu People's Hospital, Yangzhou, China
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