Cryptocarya alba (Peumo): an endemic Chilean tree with phytochemicals with bioactive potential

Gonzalo Fuentes-Barros^1,2Sebastián Castro-Saavedra^1,3Nicolas Montalva^4,5Marco Mellado⁶Antonia Diaz-Valdés^4,7,8Claudia Guerrero²Javier Echeverria^3*

• ¹SAPHYCHEM, Santiago, Chile
• ²Programa de Doctorado en Políticas Públicas, Universidad Mayor, Santiago, Chile
• ³Departamento de Ciencias del Ambiente, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile
• ⁴Centro de Investigación en Sociedad y Salud, Facultad de Ciencias Sociales y Artes, Universidad Mayor, Santiago, Chile
• ⁵Núcleo Milenio en Sociomedicina (SocioMed), Santiago, Chile
• ⁶Centro de Investigación en Ingeniería de Materiales, Universidad Central de Chile,, Santiago, Chile
• ⁷Facultad de Ciencias Sociales y Artes, Psicología, Universidad Mayor, Santiago, Chile
• ⁸Centro de Gerociencia para la Salud Cerebral y el Metabolismo, Santiago, Chile

Background: Cryptocarya alba (Mol.) Looser [Lauraceae], known as peumo, is an endemic species of the central Chilean landscape. C. alba has an essential ecological role in the threatened sclerophyllous forest, with traditional uses of leaves, bark, and fruits, and the biotechnological and pharmacological potential of its phytochemicals. Purpose: The aim is to present the first comprehensive review of the current state of knowledge regarding traditional uses, ethnopharmacology, chemical composition, pharmacokinetic profile, and biological activities of C. alba. Methodology: Literature data on the traditional uses, ethnopharmacology, chemistry, and bioactivity of C. alba were primarily obtained from digital databases, including Scopus®, ScienceDirect®, SciFinder®, PubMed®, SciELO, and Google Scholar®, as well as from the scientific journal publishers' platforms associated with these databases. Results and discussion: Traditional uses include its role as a food source for prehistoric populations and ethnomedicinal applications for liver diseases, rheumatism, and infections. The aerial parts are rich in polyphenols, including chlorogenic acid, epicatechin, procyanidins, quercitrin, rutin, and hyperoside, as well as essential oils derived from the leaves. While it contains various alkaloids, only reticuline is present in significant amounts, contributing to the species' highly variable chemical composition. Studies evaluating the biological and pharmacological properties of its extracts and constituents are limited to a few in vitro and in vivo studies; to date, no preliminary or clinical studies are available. Conclusion: The review highlights the entire existing ethnographic and cultural context of C. alba, revealing a significant gap in information about the species." Although there is a strong historical component, it supports the bioactivity of its main secondary metabolites, given its chemical and pharmacological profile. Given the limited nature of current biological and pharmacological evaluation studies, future research should focus on advancing preclinical and clinical trials, as well as toxicology studies, to ensure the safe and effective use of this approach.