REVIEW article
Front. Pharmacol.
Sec. Gastrointestinal and Hepatic Pharmacology
Research Progress on the Regulatory Effects and Mechanisms of Natural Active Products on Intestinal Barrier Function
Provisionally accepted
- 兰州联勤保障部队第940医院, 甘肃兰州, China
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As a key defense line for the body to resist pathogens and maintain internal environment stability, the intestinal barrier is crucial for maintaining human health, and its functional damage is closely related to the occurrence of various intestinal diseases, especially in the hypoxic environment of high altitude, the problem of intestinal barrier damage is more prominent. Natural active products are widely sourced and exhibit unique potential in regulating intestinal barrier function due to their multi-target and low-toxicity characteristics. This article comprehensively reviews the prevention and treatment effects of natural active products on common intestinal diseases and high-altitude intestinal injury, focusing on elucidating the mechanism by which they regulate intestinal barrier function through eight key signaling pathways such as NF-κB, Wnt/β-catenin, and mTOR, in which the HIF family is a key factor in regulating hypoxic stress response, and this signaling pathway is the "lifeline" for cells to cope with hypoxia, emphasizing its application potential in the prevention and treatment of high-altitude intestinal barrier injury, and providing a theoretical basis for the development of natural drugs for high-altitude environments and related intestinal diseases.
Keywords: Intestinal barrier1, natural active products2, intestinal diseases3, high altitude4, Gutmicrobiota5, signaling pathway6
Received: 26 Jul 2025; Accepted: 03 Nov 2025.
Copyright: © 2025 Z. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: FYX Z, 604091322@qq.com
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