ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Ethnopharmacology
Sporoderm-Removed Ganoderma lucidum Spore Powder (S-GLSP) alleviates neuroinflammation injury by regulating microglial polarization through inhibition of NLRP3 inflammasome activation
Provisionally accepted
- 1Anhui University of Chinese Medicine, Hefei, China
- 2The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China
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Abstract Introduction: Sporoderm-Removed Ganoderma lucidum Spore Powder (S-GLSP), derived from the spores of the medically valued fungus Ganoderma lucidum, exhibits diverse pharmacological activities and shows considerable potential in the treatment of Alzheimer's disease (AD). However, its underlying mechanisms of action remain incompletely elucidated. This study aims to investigate the protective effects of S-GLSP against AD and to explore the molecular mechanisms involved.
Keywords: Sporoderm-Removed Ganoderma lucidum Spore Powder, Alzheimer's disease, microglial polarization, Neuroinflammation, NLRP3 inflammasome
Received: 05 Sep 2025; Accepted: 12 Nov 2025.
Copyright: © 2025 Li, Huang, Zhou, Yao, Cai and Ye. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Biao Cai, caibiao@ahtcm.edu.cn
Shu Ye, yeshu@ahtcm.edu.cn
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.