REVIEW article
Front. Pharmacol.
Sec. Gastrointestinal and Hepatic Pharmacology
This article is part of the Research TopicNatural compounds in peptic ulcer treatment: Efficacy, Mechanisms, and Clinical prospectsView all articles
Research progress on the use of polyphenols in the treatment of Crohn's disease
Provisionally accepted
- 1Nanbu people's hospital, --Select City-nanchong-nanbu-, China
- 2Department of Pharmacy, The Affiliated Tianfu Hospital of Southwest Medical University, MeiShan 620000, China., mei shan, China
- 3Sichuan Provincial People's Hospital Medical Group Sichuan Investment Xichang Hospital, Xichang 615000, China, xi chang, China
- 4Department of Pharmacy, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China., chengdu, China
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Crohn's disease (CD) is a chronic inflammatory bowel disease (IBD), and its specific etiology is still unclear. However, it is currently widely believed that this disease is the result of interactions among four main factors: host genetic factors, environmental factors, dysbiosis of the gut microbiota, and an abnormal immune system response. In recent years, polyphenolic compounds have become a research hotspot due to their anti-inflammatory, antioxidant, and microbial regulatory properties, demonstrating potential application value in the treatment of CD. This review aimed to explore the mechanism of action of polyphenolic compounds in the treatment of CD, as well as their progress in animal model research and clinical practice.
Keywords: Polyphenols, Crohn's disease, anti-inflammatory, antioxidant, inflammatory bowel disease
Received: 14 Sep 2025; Accepted: 11 Nov 2025.
Copyright: © 2025 Zhong, Dai, Li, Yang and Zheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jie Xianmei Yang, yangjiepanda@126.com
Xi Xi Zheng, zhengxi198668@163.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.