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CORRECTION article

Front. Pharmacol., 11 December 2025

Sec. Pharmacology of Anti-Cancer Drugs

Volume 16 - 2025 | https://doi.org/10.3389/fphar.2025.1754450

Correction: Anticancer effects of OSW-1 on glioma cells via regulation of the PI3K/AKT signal pathway: a network pharmacology approach and experimental validation in vitro and in vivo

This article is a correction to:

  1. Anticancer effects of OSW-1 on glioma cells via regulation of the PI3K/AKT signal pathway: A network pharmacology approach and experimental validation in vitro and in vivo

    1. Read original article
Zhixin ZhanZhixin ZhanZiqiang LiuZiqiang LiuChaochao ZhangChaochao ZhangHaijun GaoHaijun GaoJiacheng LaiJiacheng LaiYong Chen Yong Chen*Haiyan Huang Haiyan Huang*
  • Department of Neurosurgery, The First Hospital of Jilin University, Changchun, China

A Correction on
Anticancer effects of OSW-1 on glioma cells via regulation of the PI3K/AKT signal pathway: a network pharmacology approach and experimental validation in vitro and in vivo

by Zhan Z, Liu Z, Zhang C, Gao H, Lai J, Chen Y and Huang H (2022). Front. Pharmacol. 13:967141. doi: 10.3389/fphar.2022.967141

There was a mistake in Figure 8E as published. The Total AKT1 band was inadvertently replaced with a duplicated β-actin band during figure assembly. The corrected Figure 8 appears below.

Figure 8
Panel A shows nude mice from the control and OSW-1 groups. Panel B depicts a line graph comparing tumor volume over 21 days, with OSW-1 showing reduced growth. Panel C presents a bar graph highlighting lower tumor weight in the OSW-1 group. Panel D displays a line graph of stable mouse weights for both groups. Panel E includes a Western blot and a bar graph illustrating protein expression levels, with marked differences in p-PI3K/PI3K and p-AKT1/AKT1 between groups.

Figure 8. OSW-1 inhibited tumor growth in the xenograft model mice (A) The tumors of control mice and OSW-1-treated mice were extracted and photographed (B,C) Inhibitions in the average volume and weight of glioma xenografts were observed after 21 days of OSW-1 treatment (D) Body weight changes of mice during 21 days of exposure (E) Western blotting of tumor tissue lysates. *p < 0.05, **p < 0.01, compared to the control group.

The original article has been updated.

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Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Keywords: OSW-1, glioma, network pharmacology, cell cycle, apoptosis, Pi3k/ AKt

Citation: Zhan Z, Liu Z, Zhang C, Gao H, Lai J, Chen Y and Huang H (2025) Correction: Anticancer effects of OSW-1 on glioma cells via regulation of the PI3K/AKT signal pathway: a network pharmacology approach and experimental validation in vitro and in vivo. Front. Pharmacol. 16:1754450. doi: 10.3389/fphar.2025.1754450

Received: 26 November 2025; Accepted: 05 December 2025;
Published: 11 December 2025.

Edited and reviewed by:

Muhammad Umer Farooq Awan, Government College University, Pakistan

Copyright © 2025 Zhan, Liu, Zhang, Gao, Lai, Chen and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Yong Chen, Y2hlbl95b25nQGpsdS5lZHUuY24=; Haiyan Huang, aHVhbmdoeUBqbHUuZWR1LmNu

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.