ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Cardiovascular and Smooth Muscle Pharmacology
Successful Anesthesia Management for Middle Cerebral Artery Thrombectomy in a Patient with Asynchronous Cardio-Cerebral Infarction: A Case Report
Provisionally accepted
- Qingdao Central Hospital, Qingdao, China
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Background: Cardio-cerebral infarction (CCI) is a rare syndrome characterized by acute ischemic stroke (AIS) occurring shortly after acute myocardial infarction (AMI). Currently, there are no evidence-based guidelines for perioperative anesthesia management in patients with CCI. Case summary: A 58-year-old male underwent coronary stent implantation for acute myocardial infarction (AMI) four days prior and was admitted for emergency mechanical thrombectomy due to occlusion of the right middle cerebral artery. Preoperative transthoracic echocardiography revealed left ventricular systolic dysfunction (ejection fraction < 40%), segmental wall motion abnormalities, and a left ventricular apical thrombus, this case extends beyond simple post-myocardial infarction thromboembolism because the patient's AIS occurred in the specific context of acute, severe cardiac dysfunction (EF <40%) with a documented left ventricular thrombus—a direct embolic source stemming from the recent AMI. This fulfills the criteria for "asynchronous cardio-cerebral infarction", where the brain insult is a direct consequence of the cardiac event within a short temporal window. Anesthesia was managed using a non-intubated general anesthesia approach, involving titration of sedation with sufentanil and remifentanil, combined with norepinephrine to maintain mean arterial pressure (MAP) within ±20% of baseline. The risk of ischemia and hemorrhage was balanced with restrictive fluid management and continuous infusion of tirofiban. Intraprocedural hemodynamics remained stable, and the procedure was successfully completed. The patient was transferred to the general ward on postoperative day three and discharged on day eleven. Troponin I and brain natriuretic peptide (BNP) levels showed a downward trend, with no evidence of heart failure, hemorrhagic transformation, or acute kidney injury. Conclusion: In this case of CCI patients, immediate echocardiography was helpful in quickly assessing cardiac function and determining the source of the thrombus. Non-invasive general anesthesia was beneficial in maintaining hemodynamic stability and airway safety. The multidisciplinary individualized anesthesia plan developed in this challenging scenario may provide practical references for perioperative management of similar high-risk CCI patients, but its general applicability still needs to be verified in larger-scale studies.
Keywords: Anesthesia management, Asynchronous Cardio-Cerebral Infarction, Echocardiography, Hemodynamic stability, Middle Cerebral Artery Thrombectomy
Received: 23 Sep 2025; Accepted: 13 Feb 2026.
Copyright: © 2026 Zhang, Zhao, Wu, Wang and Song. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shoushi Wang
Tingting Song
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