REVIEW article
Front. Pharmacol.
Sec. Cardiovascular and Smooth Muscle Pharmacology
This article is part of the Research TopicMicroRNA Secretion and Delivery: Mechanisms, Biomarkers, and Therapeutic InnovationsView all 6 articles
Application of the miRNAs as biomarkers and therapeutic strategies in periodontal inflammation
Provisionally accepted
Sarmistha Saha1*
Nadezhda Sachivkina2Olga Pilshchikova2Alexandr Muraev2Sergey Ivanov2Sergey G. Ivashkevih2Regina Gurina2- 1GLA University, Mathura, India
- 2Rossijskij universitet druzby narodov, Moscow, Russia
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Inflammatory and host immunological responses to bacterial tooth infections contribute to the development of periodontal disease. MiRNAs (miRNAs) play a critical role in regulating these immunological and inflammatory responses. miRNAs influence both innate and adaptive immunity in periodontal disease, affecting the functions of T and B cells, neutrophils, macrophages, and dendritic cells. This review examines the regulatory roles of miRNAs in periodontal tissues and evaluates their potential as therapeutic agents and biomarkers. Upregulated miRNAs identified include miR-146a, miR-29, miR-15, miR-148, and miR-223, while miR-31, miR-92, and miR-451 are downregulated. The review emphasizes the altered expression of miRNAs in periodontitis models. Selective targeting of miRNA pathways, enabled by gain or loss-of-function approaches, represents a promising strategy for therapeutic intervention. Additionally, the stability of miRNAs in gingival crevicular fluid and their association with specific features of periodontal disease underscore their potential as indicators of disease progression or tissue recovery.
Keywords: inflammatory mediators, mir-142-3p, MiR-203, miRNA, Periodontitis
Received: 05 Oct 2025; Accepted: 30 Jan 2026.
Copyright: © 2026 Saha, Sachivkina, Pilshchikova, Muraev, Ivanov, Ivashkevih and Gurina. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Sarmistha Saha
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