ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Ethnopharmacology
Eubacterium sp. mediates the anti-Obesity effect of Lotus leaf extract via Brown Adipose Tissue activation and White Fat Browning
Provisionally accepted
- Guizhou Medical University, Guiyang, China
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Nelumbinis folium [Nelumbonaceae ; Nelumbo nucifera Gaertn.] is a traditional Chinese medicine. Although studies have reported the efficacy of lotus leaf in weight management, the underlying molecular pathways necessitate further studies. This study aimed to elucidate the effects of lotus leaf on gut microbiota and their metabolites, especially long-chain fatty acids (LCFA), and measure how the effects of lotus leaf on gut microbiota help control obesity. The 12-week Lotus Leaf Extract (LLE) treatment mitigated weight gain, reduced liver and white adipose tissue mass, and activated brown adipose tissue in high-fat diet-induced obese mice, indicating enhanced energy metabolism. LLE reversed gut microbiota dysbiosis by enriching Eubacterium sp. in the gut. Microbiota transplantation indicated that Eubacterium sp. contributes to fat browning and thermogenesis, thereby alleviating host obesity, glucose homeostasis, dyslipidemia, and hepatic steatosis. In addition, Eubacterium sp. significantly increased the levels of margaroleic acid in mouse serum. In summary, the study found that lotus leaf extract can prevent obesity by modulating the gut microbiota, which in turn activates BAT activity and promotes the browning of WAT.
Keywords: BAT, Eubacterium sp., Lotus leaf, microbiota transplantation, Obesity, WAT
Received: 18 Oct 2025; Accepted: 28 Jan 2026.
Copyright: © 2026 Zou, Yuan, Wang and Liao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shang-Gao Liao
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