ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Experimental Pharmacology and Drug Discovery
Evaluation of potential of Revstone ® on gentamicin induced renal toxicity in Wistar Rats: A Comparative Study of Capsule and Syrup Forms
Provisionally accepted
- Other
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Introduction- Revstone ® a polyherbal formulation available in capsule and syrup forms, is designed to treat kidney related disorders. However, its renoprotective efficacy remains insufficiently validated. The present study aimed to evaluate and compare the renoprotective potential of Revstone ® capsule and syrup formylations in Wistar rats Objective- To assess the acute toxicity profile of Revstone® capsule and syrup following OECD guidelines and to compare their efficacy in reversing renal damage based on biochemical, histological, and functional markers. Methodology- Acute oral toxicity testing was determined as per OECD 423 guidelines, observing rats for 14 days for mortality, behavioral and clinical changes, body weight variations, and gross necropsy findings. For efficacy evaluation, nephrotoxicity was induced by gentamicin (80 mg/kg i.p. for 7 days). Rats were divided into seven groups: normal control, disease control, Revstone® syrup (low and high dose), Revstone® capsule (low and high dose), and standard drug control (Valsartan 10 mg/kg). Renal function was assessed from serum creatinine, blood urea nitrogen, and uric acid levels. Oxidative stress markers such as malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) and Histopathological evaluation of kidney tissue was performed. Data were analyzed using one-way ANOVA followed by Tukey’s post-hoc test (p < 0.05). Results: Gentamicin significantly elevated renal markers (p <0.001). Revstone® syrup at high dose markedly reduced creatinine (p<0.001), while both formulations improved oxidative stress and renal histology. The syrup formulation was more effective, indicating its potential for future clinical application. Conclusion- Revstone® capsule and syrup showed significant renoprotective activity in gentamicin-induced nephrotoxicity in rats
Keywords: Acute oral toxicity, Nephroprotective, Oxidative Stress, Polyherbal formulation, Revstone®
Received: 11 Dec 2025; Accepted: 05 Feb 2026.
Copyright: © 2026 Dawane, Dhande, Shukla and Dhakne. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Priti Dhande
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