Correction: Erythropoietin Mitigates Diabetic Nephropathy by Restoring PINK1/Parkin-Mediated Mitophagy

Xinyao Yi¹Yan Wenhui¹Tingli Guo¹Na Liu¹Zhuanzhuan Wang¹Jia Shang¹Xiaotong Wei¹Xin Cui¹Yuzhuo Sun¹Shuting Ren^2*Lina Chen^1,3*

• ¹Department of Pharmacology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi'an, China
• ²Department of Pathology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi'an, China
• ³Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi’an Jiaotong University, Xi'an, China

There was a mistake in figure 6 as published. In Figure 6, the GAPDH band shown in panels E and F, as well as GAPDH in panels H and J, are identical. This is because the representative images of target proteins were obtained from the same batch of gels, and therefore the corresponding GAPDH controls were displayed. However, due to our layout mistake, the reuse of these internal controls was not clearly indicated, which may have appeared as repeated patterns during review. The corrected figure will not affect the results and conclusions. The corrected figure 6 appears below.The original version of this article has been updated. There was a mistake in the caption of figure 6 as published. Due to the correction of panels E, F, H and J in figure 6. The relevant caption will also need to be adjusted. The original caption of figure 6 The original version of this article has been updated. Adding/removing text Due to the correction of figure 6, the related figure information in the main text of this paper will also need to be adjusted. The original text is "According to the in vitro results, the protective effects of EPO on mesangial cells exposed to HG were associated with PINK1/Parkin-mediated mitophagy. So we further detected the mRNA and protein levels of genes in PINK1/Parkinmediated mitophagy in the kidney tissues. Compared with mice in the control group, the ratio of LC3B-Ⅱ/LC3B-Ⅰ (Figure 6E), the mRNA and protein levels of PINK1 (Figures 6C,G), and Mfn-2 protein level (Figure 6J) in the kidney tissues of mice of Model group were significantly decreased, while P62 and Drp-1 were significantly increased in terms of the mRNA and protein levels (Figures 6B,F,I), resulting in the blockage of autophagic flux and inhibited level of PINK1/Parkin-mediated mitophagy. However, there was no difference in the mRNA expression of LC3 in these two groups (Figure 6A), and the mRNA and protein levels of Parkin were elevated in the model group (Figures 6D,H). Of note, EPO administration partly reversed these changes as indicated by the significantly increased ratio of LC3B-II/LC3B-I (Figure 6E) as well as expressions of PINK1 (Figures 6C,G) and Mfn-2 (Figure 6J), and decreased expressions of P62 (Figures 6B,F) and Drp-1 (Figure 6I). These results suggested that EPO could mitigate the blockage of autophagic flux and improve the level of PINK1/Parkin-mediated mitophagy".A correction has been made to the section 3.6 (paragraph number 255):"According to the in vitro results, the protective effects of EPO on mesangial cells exposed to HG were associated with PINK1/Parkin-mediated mitophagy. So we further detected the mRNA and protein levels of genes in PINK1/Parkin-mediated mitophagy in the kidney tissues. Compared with mice in the control group, the ratio of LC3B-Ⅱ/LC3B-Ⅰ (Figure . 6E,F), the mRNA and protein levels of PINK1 (Figure . 6C,E,F), and Mfn-2 protein level (Figure . 6G,H) in the kidney tissues of mice of Model group were significantly decreased, while P62 and Drp-1 were significantly increased in terms of the mRNA and protein levels (Figure . 6B, E-H), resulting in the blockage of autophagic flux and inhibited level of PINK1/Parkin-mediated mitophagy. However, there was no difference in the mRNA expression of LC3 in these two groups (