MINI REVIEW article
Front. Pharmacol.
Sec. Translational Pharmacology
Nanotechnology-Enabled Delivery of Luteolin: A Comprehensive Review on Multidisease Therapeutic Applications
Yutong Li 1
Hongxuan Chen 2
Yong Lu 1
Shenghui Zhong 2
Xianfu Wu 1
1. National Institutes for Food and Drug Control, Beijing, China
2. School of Basic Medical Sciences, Yichun University, Yichun, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Abstract
Luteolin is a natural flavonoid compound widely found in various plants, known for its antioxidant, anti-inflammatory, cardiovascular protective and anti-tumor activities. However, its low bioavailability due to rapid metabolism and low solubility hinders its clinical application. In recent years, with the development of nanotechnology, luteolin combined with nanomaterials to form nanocomposites has shown promising drug delivery performance and therapeutic effects in numerous diseases. This article reviews the latest research progress on luteolin nanocomposites in disease treatment, exploring their potential applications in cancer, diabetes, cardiovascular diseases, neurological disorders, and other conditions.
Summary
Keywords
Disease treatment, Luteolin, Nanocomposites, potential applications, Research progress
Received
21 January 2026
Accepted
17 February 2026
Copyright
© 2026 Li, Chen, Lu, Zhong and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Shenghui Zhong; Xianfu Wu
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.