Frontiers in Pharmacology | Drug Metabolism and Transport

Original Research

Published on 30 Aug 2022

The impact of CYP2D6*41 on CYP2D6 enzyme activity using phenotyping methods in urine, plasma, and saliva

in Drug Metabolism and Transport

Ye Jin
Shuquan Zhang
Pei Hu
Xin Zheng
Xiaoduo Guan
Rui Chen
Shuyang Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.940510

3,356 views
3 citations

Original Research

Published on 29 Aug 2022

Population pharmacokinetics of intravenous colistin sulfate and dosage optimization in critically ill patients

in Drug Metabolism and Transport

Yue-liang Xie
Xin Jin
Shan-shan Yan
Cui-fang Wu
Bi-xiao Xiang
Hui Wang
Wu Liang
Bing-chang Yang
Xue-fei Xiao
Zhi-ling Li

Frontiers in Pharmacology

doi 10.3389/fphar.2022.967412

4,914 views
22 citations

Original Research

Published on 29 Aug 2022

Improved pharmacokinetics of tenofovir ester prodrugs strengthened the inhibition of HBV replication and the rebalance of hepatocellular metabolism in preclinical models

in Drug Metabolism and Transport

Xiaodan Hong
Zuhuan Cai
Fang Zhou
Xiaoliang Jin
Guangji Wang
Bingchen Ouyang
Jingwei Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.932934

7,563 views
17 citations

Original Research

Published on 29 Aug 2022

Study on plasma metabolomics for HIV/AIDS patients treated by HAART based on LC/MS-MS

in Drug Metabolism and Transport

Donghui Lao
Rong Liu
Jianying Liang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.885386

3,600 views
7 citations

Original Research

Published on 26 Aug 2022

Pharmacokinetic and pharmacodynamic similarity evaluation between an insulin glargine biosimilar product and Lantus® in healthy subjects: Pharmacokinetic parameters of both parent insulin glargine and M1 were used as endpoints

in Drug Metabolism and Transport

Yiya Wang
Ying Zhou
Juefang Ding
Xianjing Li
Fengxue Guo
Jianfei Zhang
Li Ding

Frontiers in Pharmacology

doi 10.3389/fphar.2022.962201

4,268 views
4 citations

Original Research

Published on 26 Aug 2022

Application of physiologically-based pharmacokinetic/pharmacodynamic models to evaluate the interaction between nifedipine and apatinib

in Drug Metabolism and Transport

Hongrui Liu
Yiqun Yu
Lu Liu
Chunyan Wang
Nan Guo
Xiaojuan Wang
Xiaoqiang Xiang
Bing Han

Frontiers in Pharmacology

doi 10.3389/fphar.2022.970539

3,286 views
6 citations

Original Research

Published on 24 Aug 2022

Pharmacokinetic assessment of vancomycin in critically ill patients and nephrotoxicity prediction using individualized pharmacokinetic parameters

in Drug Metabolism and Transport

Parisa Ghasemiyeh
Afsaneh Vazin
Farid Zand
Elham Haem
Iman Karimzadeh
Amir Azadi
Mansoor Masjedi
Golnar Sabetian
Reza Nikandish
Soliman Mohammadi-Samani

Frontiers in Pharmacology

doi 10.3389/fphar.2022.912202

5,429 views
8 citations

Original Research

Published on 23 Aug 2022

A randomized, double-blind, parallel control study to evaluate the biosimilarity of QL1209 with Perjeta® in healthy male subjects

in Drug Metabolism and Transport

Yuanyuan Sun
Heng Yang
Xiaoyan Yang
Shuang Yang
Can Guo
Honghui Chen
Chang Cui
Yuxia Xiang
Guoping Yang
Jie Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.953641

2,891 views
2 citations

Original Research

Published on 23 Aug 2022

Dex modulates the balance of water-electrolyte metabolism by depressing the expression of AVP in PVN

in Drug Metabolism and Transport

Wenzhi Yang
Hao Li
Zhongle Cheng
You Lu
Wuli Li
Jun Feng
Liecheng Wang
Juan Cheng

Frontiers in Pharmacology

doi 10.3389/fphar.2022.919032

4,410 views
14 citations

Original Research

Published on 22 Aug 2022

Risk assessment and molecular mechanism study of drug-drug interactions between rivaroxaban and tyrosine kinase inhibitors mediated by CYP2J2/3A4 and BCRP/P-gp

in Drug Metabolism and Transport

Tingting Zhao
Xuening Li
Yanwei Chen
Jie Du
Xiaodong Chen
Dalong Wang
Liyan Wang
Shan Zhao
Changyuan Wang
Qiang Meng

Frontiers in Pharmacology

doi 10.3389/fphar.2022.914842

4,357 views
13 citations

Clinical Trial

Published on 22 Aug 2022

Dose-dependent reduction of lymphocyte count and heart rate after multiple administration of LC51-0255, a novel sphingosine-1-phosphate receptor 1 modulator, in healthy subjects

in Drug Metabolism and Transport

Inyoung Hwang
Sang Won Lee
Jaeseong Oh
SeungHwan Lee
In-Jin Jang
Kyung-Sang Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2022.930615

1,927 views
3 citations

Original Research

Published on 22 Aug 2022

Cytochrome P450-mediated antiseizure medication interactions influence apoptosis, modulate the brain BAX/Bcl-XL ratio and aggravate mitochondrial stressors in human pharmacoresistant epilepsy

in Drug Metabolism and Transport

Chaitali Ghosh
Rosemary Westcott
Emilio Perucca
Mohammed Hossain
William Bingaman
Imad Najm

Frontiers in Pharmacology

doi 10.3389/fphar.2022.983233

4,203 views
4 citations

Clinical Trial

Published on 19 Aug 2022

A single-dose, randomized, open-labeled, parallel-group study comparing the pharmacokinetics, pharmacodynamics and safety of leuprolide acetate microspheres 3.75 mg and Enantone® 3.75 mg in healthy male subjects

in Drug Metabolism and Transport

Xingjiang Hu
Qiao Zhang
Yunliang Zheng
You Zhai
Nana Xu
Qingwei Zhao
Jian Liu
Longyan Wan
Jindan Luo

Frontiers in Pharmacology

doi 10.3389/fphar.2022.946505

5,603 views
2 citations

Original Research

Published on 17 Aug 2022

Genome-wide microRNA profiles identify miR-107 as a top miRNA associating with expression of the CYP3As and other drug metabolizing cytochrome P450 enzymes in the liver

in Drug Metabolism and Transport

Marwa Tantawy
Joseph M. Collins
Danxin Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.943538

2,966 views
10 citations

Methods

Published on 17 Aug 2022

Simultaneous absolute protein quantification of seven cytochrome P450 isoforms in rat liver microsomes by LC-MS/MS-based isotope internal standard method

in Drug Metabolism and Transport

Fulin Jiang
Chang Zhang
Zihan Lu
Jingyu Liu
Peiqing Liu
Min Huang
Guoping Zhong

Frontiers in Pharmacology

doi 10.3389/fphar.2022.906027

3,645 views
2 citations

Original Research

Published on 16 Aug 2022

Evaluation of commonly used cardiovascular drugs in inhibiting vonoprazan metabolism in vitro and in vivo

in Drug Metabolism and Transport

Yiran Wang
Jihua Shi
Dapeng Dai
Jianping Cai
Shuanghu Wang
Yun Hong
Shan Zhou
Fangling Zhao
Quan Zhou
Peiwu Geng

Frontiers in Pharmacology

doi 10.3389/fphar.2022.909168

5,436 views
6 citations