Frontiers in Pharmacology | Drug Metabolism and Transport

Original Research

Published on 12 May 2022

Application of Physiologically Based Pharmacokinetic Modeling in Preclinical Studies: A Feasible Strategy to Practice the Principles of 3Rs

in Drug Metabolism and Transport

Yawen Yuan
Qingfeng He
Shunguo Zhang
Min Li
Zhijia Tang
Xiao Zhu
Zheng Jiao
Weimin Cai
Xiaoqiang Xiang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.895556

5,523 views
14 citations

Original Research

Published on 12 May 2022

In Silico Screening and Validation of PDGFRA Inhibitors Enhancing Radioiodine Sensitivity in Thyroid Cancer

in Drug Metabolism and Transport

Xuefei Yu
Xuhang Zhu
Lizhuo Zhang
Jiang-Jiang Qin
Chunlai Feng
Qinglin Li

Frontiers in Pharmacology

doi 10.3389/fphar.2022.883581

3,787 views
10 citations

Original Research

Published on 10 May 2022

Pharmacokinetic Characteristics of Siponimod in Healthy Volunteers and Patients With Multiple Sclerosis: Analyses of Published Clinical Trials

in Drug Metabolism and Transport

Chen Chaoyang
Dong Xiu
Wei Ran
Ma Lingyun
Zhao Simiao
Li Ruoming
Zhang Enyao
Zhou Ying
Cui Yimin
Liu Zhenming

Frontiers in Pharmacology

doi 10.3389/fphar.2022.824232

3,909 views
2 citations

Original Research

Published on 04 May 2022

In vitro Evaluation of Isoniazid Derivatives as Potential Agents Against Drug-Resistant Tuberculosis

in Drug Metabolism and Transport

Joaquim Trigo Marquês
Catarina Frazão De Faria
Marina Reis
Diana Machado
Susana Santos
Maria da Soledade Santos
Miguel Viveiros
Filomena Martins
Rodrigo F. M. De Almeida

Frontiers in Pharmacology

doi 10.3389/fphar.2022.868545

3,696 views
6 citations

Original Research

Published on 04 May 2022

Investigation of the Uptake and Transport of Aspirin Eugenol Ester in the Caco-2 Cell Model

in Drug Metabolism and Transport

Qi Tao
Zhe Qin
Xi-Wang Liu
Zhen-Dong Zhang
Shi-Hong Li
Li-Xia Bai
Jian-Yong Li
Ya-Jun Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.887598

3,529 views
4 citations

Original Research

Published on 27 Apr 2022

Effect of Baicalein on the Pharmacokinetics of Cilostazol and Its Two Metabolites in Rat Plasma Using UPLC-MS/MS Method

in Drug Metabolism and Transport

Qinghua Weng
Chaojie Chen
Jianhua Xiong
Ya-Nan Liu
Xinxin Pan
Ju Cui
Jian-Ping Cai
Ren-Ai Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2022.888054

2,489 views
3 citations

Original Research

Published on 26 Apr 2022

Compatibility of Fuzi and Ginseng Significantly Increase the Exposure of Aconitines

in Drug Metabolism and Transport

Ze-Yan Chen
Xu-Ya Wei
Zi-Dong Qiu
Yun Huang
Ting Tan
Yu-Lin Feng
Juan Guo
Guang-Hong Cui
Lu-Qi Huang
Chang-Jiang-Sheng Lai

Frontiers in Pharmacology

doi 10.3389/fphar.2022.883898

3,503 views
9 citations

Original Research

Published on 25 Apr 2022

Engineering of Stimulus-Responsive Pirfenidone Liposomes for Pulmonary Delivery During Treatment of Idiopathic Pulmonary Fibrosis

in Drug Metabolism and Transport

Meishan Han
Yingjian Song
Sha Liu
Xiaoyan Lu
Linyu Su
Meixuan Liu
Xiaosu Zhu
Kaoxiang Sun
Yanan Lu
Aiping Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.882678

4,704 views
16 citations

Original Research

Published on 20 Apr 2022

Single and Repeated Doses of EGb 761® do not Affect Pharmacokinetics or Pharmacodynamics of Rivaroxaban in Healthy Subjects

in Drug Metabolism and Transport

Robert Hoerr
Andrea Zimmermann
Friedeborg Seitz
Angelika Dienel

Frontiers in Pharmacology

doi 10.3389/fphar.2022.868843

5,534 views
2 citations

Original Research

Published on 20 Apr 2022

Dynamics of Erythroferrone Response to Erythropoietin in Rats

in Drug Metabolism and Transport

Peng Xu
Raymond S. M. Wong
Wojciech Krzyzanski
Xiaoyu Yan

Frontiers in Pharmacology

doi 10.3389/fphar.2022.876573

2,942 views
5 citations

Original Research

Published on 20 Apr 2022

The Unusual Cosubstrate Specificity of NQO2: Conservation Throughout the Amniotes and Implications for Cellular Function

in Drug Metabolism and Transport

Faiza Islam
Kevin K. Leung
Matthew D. Walker
Shahed Al Massri
Brian H. Shilton

Frontiers in Pharmacology

doi 10.3389/fphar.2022.838500

3,734 views
8 citations

Original Research

Published on 13 Apr 2022

Urinary Profile of Endogenous Gamma-Hydroxybutyric Acid and its Biomarker Metabolites in Healthy Korean Females: Determination of Age-Dependent and Intra-Individual Variability and Identification of Metabolites Correlated With Gamma-Hydroxybutyric Acid

in Drug Metabolism and Transport

Suji Kim
Suein Choi
Min Seo Lee
Mingyu Kim
Maria Park
Sungpil Han
Seunghoon Han
Hye Suk Lee
Sooyeun Lee

Frontiers in Pharmacology

doi 10.3389/fphar.2022.853971

3,309 views
5 citations

Original Research

Published on 11 Apr 2022

Dosage Strategy of Linezolid According to the Trough Concentration Target and Renal Function in Chinese Critically Ill Patients

in Drug Metabolism and Transport

Fan Wu
Xiao-Shan Zhang
Ying Dai
Zi-Ye Zhou
Chun-Hong Zhang
Lu Han
Fang-Min Xu
Ye-Xuan Wang
Da-Wei Shi
Guan-Yang Lin

Frontiers in Pharmacology

doi 10.3389/fphar.2022.844567

10,945 views
19 citations

Mini Review

Published on 05 Apr 2022

Gut Microbiota Metabolism of Azathioprine: A New Hallmark for Personalized Drug-Targeted Therapy of Chronic Inflammatory Bowel Disease

in Drug Metabolism and Transport

Slavica Lazarević
Maja Đanic
Hani Al-Salami
Armin Mooranian
Momir Mikov

Frontiers in Pharmacology

doi 10.3389/fphar.2022.879170

7,350 views
17 citations

Original Research

Published on 05 Apr 2022

Single Dose Comparative Bioavailability Study of Lisdexamfetamine Dimesylate as Oral Solution Versus Reference Hard Capsules in Healthy Volunteers

in Drug Metabolism and Transport

Simona Rizea-Savu
Simona Nicoleta Duna
Dimitrios Panagiotopoulos
Roxana Colette Sandulovici

Frontiers in Pharmacology

doi 10.3389/fphar.2022.881198

8,501 views
1 citation

Original Research

Published on 01 Apr 2022

Identification of Natural Products as SENP2 Inhibitors for Targeted Therapy in Heart Failure

in Drug Metabolism and Transport

Somayye Taghvaei
Farzaneh Sabouni
Zarrin Minuchehr

Frontiers in Pharmacology

doi 10.3389/fphar.2022.817990

4,260 views
13 citations