Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 14 Feb 2025

Zebularine showed anti-tumor efficacy in clear cell renal cell carcinoma

in Experimental Pharmacology and Drug Discovery

Haoyu Xu
Senlin Peng
Junwu Li
Yuanyuan Bai
Guozhi Zhao
Simin Liang
Wei Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1531056

1,145 views

Original Research

Published on 14 Feb 2025

COL7A1 indicates crucial potential as a basal membrane-related prognostic biomarker and therapeutic target in lung adenocarcinoma

in Experimental Pharmacology and Drug Discovery

Jiao Zhang
Rui Zi
Ping Hu
Zongying Jiang
Ye Lv
Haixia Zhang
Yanjiao Zhao
Yan Wang
Lujun Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1543193

1,034 views

Original Research

Published on 14 Feb 2025

Unveiling the effects of Rosa canina oligosaccharide liposome on neuropathic pain and motor dysfunction following spinal cord injury in rats: relevance to its antioxidative effects

in Experimental Pharmacology and Drug Discovery

Yasaman Ahmadpour
Gholamreza Bahrami
Elham Arkan
Fatemeh Abbaszadeh
Faranak Aghaz
Sajad Fakhri
Javier Echeverría

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1533025

1,605 views
1 citation

Review

Published on 13 Feb 2025

Recent development of mitochondrial metabolism and dysfunction in osteoarthritis

in Experimental Pharmacology and Drug Discovery

Pengchao Guo
Ahmad Alhaskawi
Safwat Adel Abdo Moqbel
Zhijun Pan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1538662

2,943 views
2 citations

Original Research

Published on 13 Feb 2025

Saliva-derived components can enhance the performance of toluidine blue in photodynamic therapy

in Experimental Pharmacology and Drug Discovery

Nicolas Macri
Luana Mendonça Dias
Ana Claudia Pavarina
Walter L. Siqueira
Felipe Fornias Sperandio

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1538520

1,258 views

Review

Published on 13 Feb 2025

The role and application of bioinformatics techniques and tools in drug discovery

in Experimental Pharmacology and Drug Discovery

Shujun Zhang
Kaijie Liu
Yafeng Liu
Xinjun Hu
Xinyu Gu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1547131

6,036 views
1 citation

Original Research

Published on 13 Feb 2025

Development of a phenotypic screening assay to measure activation of cancer-associated fibroblasts

in Experimental Pharmacology and Drug Discovery

Marcus M. Ilg
Alice R. Lapthorn
Sophie L. Harding
Tariq Minhas
Gouri Koduri
Stephen A. Bustin
Selim Cellek

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1526495

2,651 views

Original Research

Published on 13 Feb 2025

Novel human single-domain antibodies exert potent anti-tumor activity by targeting EGF-like repeat epitope of EpCAM

in Experimental Pharmacology and Drug Discovery

Xiaofeng Zhou
Zhifang Liu
Weixiong Zhang
Lin Dai
Tao Chen
Zexiong Lin
Hong Pan
Qi Qi
Henry Wei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1530268

956 views

Review

Published on 11 Feb 2025

New strategies to enhance the efficiency and precision of drug discovery

in Experimental Pharmacology and Drug Discovery

Qi An
Liang Huang
Chuan Wang
Dongmei Wang
Yalan Tu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1550158

2,712 views
3 citations

Methods

Published on 11 Feb 2025

KGRDR: a deep learning model based on knowledge graph and graph regularized integration for drug repositioning

in Experimental Pharmacology and Drug Discovery

Huimin Luo
Hui Yang
Ge Zhang
Jianlin Wang
Junwei Luo
Chaokun Yan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1525029

1,189 views

Review

Published on 11 Feb 2025

Hepatobiliary organoid research: the progress and applications

in Experimental Pharmacology and Drug Discovery

Rui-Qi Zou
Yu-Shi Dai
Fei Liu
Si-Qi Yang
Hai-Jie Hu
Fu-Yu Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1473863

3,125 views

Original Research

Published on 11 Feb 2025

Post-treatment of rat aflatoxicosis by camel milk and silymarin

in Experimental Pharmacology and Drug Discovery

Nahla H. Hassaneen
Shabaan A. Hemeda
Abeer F. El Nahas
Ghadeer M. Albadrani
Muath Q. Al-Ghadi
Zuhair M. Mohammedsaleh
Sabreen E. Fadl
Eman M. El-Diasty
Hader I. Sakr

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1513105

996 views

Review

Published on 10 Feb 2025

Optimizing therapeutic outcomes: preconditioning strategies for MSC-derived extracellular vesicles

in Experimental Pharmacology and Drug Discovery

Yuqi Song
Fengrui Liang
Weikun Tian
Erin Rayhill
Liping Ye
Xinghan Tian

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1509418

2,693 views
3 citations

Original Research

Published on 07 Feb 2025

Anti-TNBC effects of Lappaol F by targeting epithelial-mesenchymal transition via regulation of GSK-3β/YAP/β-catenin and PI3K/AKT pathways

in Experimental Pharmacology and Drug Discovery

Qiqi Meng
Zhiping Li
Xiaofeng He
Yuanhao Hu
Guiyun Wu
Jiawen Huang
Zhuohui Luo
Yingjie Hu
Xiaoling Shen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1496511

1,429 views

Original Research

Published on 06 Feb 2025

Preclinical pharmaco-toxicological screening of biomimetic melanin-like nanoparticles as a potential therapeutic strategy for cutaneous melanoma

in Experimental Pharmacology and Drug Discovery

Iasmina Marcovici
Raul Chioibas
Istvan Zupko
Iulia Pinzaru
Alina Moaca
Adriana Ledeti
Lucian Barbu-Tudoran
Andreea Geamantan
Iasmina Predescu
Cristina Adriana Dehelean

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1487854

1,343 views
1 citation

Original Research

Published on 06 Feb 2025

Exploring the CD3/CD56/TNF-α/Caspase3 pathway in pyrethroid-induced immune dysregulation: curcumin-loaded chitosan nanoparticle intervention

in Experimental Pharmacology and Drug Discovery

Nawal Alsubaie
Yasmina M. Abd-Elhakim
Amany Abdel-Rahman Mohamed
Tarek Khamis
Mohamed M. M. Metwally
Nawal Helmi
Afnan M. Alnajeebi
Badriyah S. Alotaibi
Amirah Albaqami
Wedad Mawkili

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1505432

1,125 views