Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 29 Nov 2024

Discovery of novel PARP1/NRP1 dual-targeting inhibitors with strong antitumor potency

in Experimental Pharmacology and Drug Discovery

Juanjuan Liu
Yifei Geng
Su Jiang
Lixia Guan
Junyi Gao
Miao-Miao Niu
Jindong Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1454957

1,443 views

Editorial

Published on 29 Nov 2024

Editorial: What does experimental pharmacology and drug discovery look like in 2035?

in Experimental Pharmacology and Drug Discovery

Maria Serena Fabbrini
Riccardo Vago

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1504817

1,513 views

Original Research

Published on 28 Nov 2024

Investigation of the effects of Periplaneta americana (L.) extract on ischemic stroke based on combined multi-omics of gut microbiota

in Experimental Pharmacology and Drug Discovery

Xin Yang
Canhui Hong
Tangfei Guan
ChengGui Zhang
Peiyun Xiao
Yongshou Yang
Huai Xiao
Zhengchun He

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1429960

1,671 views
1 citation

Original Research

Published on 26 Nov 2024

Cytotoxicity of natural and synthetic cannabinoids and their synergistic antiproliferative effects with cisplatin in human ovarian cancer cells

in Experimental Pharmacology and Drug Discovery

Ying Chen
Huifang Li
Jia Liu
Jie Ni
Qicheng Deng
Haotian He
Panpan Wu
Yinsheng Wan
Navindra P. Seeram
Chang Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1496131

1,905 views
2 citations

Original Research

Published on 25 Nov 2024

Dexmedetomidine regulates the anti-oxidation and autophagy of adipose-derived stromal cells under H2O2-induced oxidative stress through Nrf2/p62 pathway and improves the retention rate of autologous fat transplantation

in Experimental Pharmacology and Drug Discovery

Zihao Li
Qing Wei
Yijun Li
Fangfang Yang
Chen Ke
Tian Li
Liqun Li
Zhongming Cai

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1453938

1,180 views

Original Research

Published on 25 Nov 2024

Preparation and characterization of Pistacia atlantica oleo-gum-resin-loaded electrospun nanofibers and evaluating its wound healing activity in two rat models of skin scar and burn wound

in Experimental Pharmacology and Drug Discovery

Ghobad Mohammadi
Mosayyeb Safari
Masoud Karimi
Amin Iranpanah
Mohammad Hosein Farzaei
Sajad Fakhri
Javier Echeverría

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1474981

2,164 views
2 citations

Original Research

Published on 21 Nov 2024

Evaluation of the inhibitory mechanism of Pennisetum glaucum (pearl millet) bioactive compounds for rheumatoid arthritis: an in vitro and computational approach

in Experimental Pharmacology and Drug Discovery

Maria Sharif
Peter John
Attya Bhatti
Rehan Zafar Paracha
Abid Majeed

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1488790

2,020 views
1 citation

Original Research

Published on 20 Nov 2024

Exploring somatic mutations in BRAF, KRAS, and NRAS as therapeutic targets in Saudi colorectal cancer patients through massive parallel sequencing and variant classification

in Experimental Pharmacology and Drug Discovery

Thamer Abdulhamid Aljuhani
Noor Ahmad Shaik
Rahaf Talal Alqawas
Rana Y. Bokhary
Mahmood Al-Mutadares
Hadiah Bassam Al Mahdi
Nuha Al-Rayes
Ashraf AbdulRahman El-Harouni
Ramu Elango
Babajan Banaganapalli

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1498295

1,788 views
1 citation

Systematic Review

Published on 18 Nov 2024

Efficacy and safety of Epimedium total flavonoids for primary osteoporosis: a systematic review and meta-analysis

in Experimental Pharmacology and Drug Discovery

Jinkun Li
Xudong Huang
Yifeng Yuan
Haixin Zhang
Hang Zhou
Wei Xiong
Yuyi Li
Zechen Zhang
Fengqing Qie
Yingdelong Mao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1505926

1,976 views

Original Research

Published on 18 Nov 2024

Integrated chemical analysis, metabolic profiling, network pharmacology, molecular docking and toxicity prediction to reveal the active ingredients and their safety of raw and prepared rhubarbs in the treatment of gastric ulcers

in Experimental Pharmacology and Drug Discovery

Chenxi Wang
Xin Zhao
Jingjing Jiang
Mengqi Jia
Wenqing Shi
Zhenghua Wu
Shiyu Feng
Guorong Fan
Yuefen Lou

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1481091

1,810 views
1 citation

Original Research

Published on 15 Nov 2024

Discovery of novel and highly potent dual-targeting PKMYT1/HDAC2 inhibitors for hepatocellular carcinoma through structure-based virtual screening and biological evaluation

in Experimental Pharmacology and Drug Discovery

Yang Yang
Yuting Wang
Jing Chen
Miao-Miao Niu
Yongbin Wang
Xing Jin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1491497

1,569 views

Original Research

Published on 14 Nov 2024

Repurposed drugs as histone deacetylase 8 inhibitors: Implications in cancer and neuropathological conditions

in Experimental Pharmacology and Drug Discovery

Mohammed Alrouji
Kumar Venkatesan
Mohammed S. Alshammari
Fahad A. Alhumaydhi
Sheeba Shafi
Sharaf E. Sharaf
Moyad Shahwan
Anas Shamsi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1488585

1,376 views

Original Research

Published on 13 Nov 2024

Glucocorticoids influence on rat hematological parameters and catalase activity

in Experimental Pharmacology and Drug Discovery

Safija Herenda
Ivana Carev
Denis Haskovic
Sabina Prevljak
Sara Causevic
Edhem Haskovic

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1367350

795 views

Review

Published on 13 Nov 2024

In-depth analysis of lupeol: delving into the diverse pharmacological profile

in Experimental Pharmacology and Drug Discovery

Aminah Dalimunthe
Mega Carensia Gunawan
Zahirah Dhiya Utari
Muhammad Riza Dinata
Princella Halim
Nathasya Estherina S. Pakpahan
Alex Insandus Sitohang
M. Andriansyah Sukarno
Yuandani
Yahdiana Harahap

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1461478

5,103 views
5 citations

Review

Published on 13 Nov 2024

β-blockers and statins: exploring the potential off-label applications in breast, colorectal, prostate, and lung cancers

in Experimental Pharmacology and Drug Discovery

Pedro Gabriel Senger Braga
Janaína da Silva Vieira
Aline Rachel Bezerra Gurgel
Patricia Chakur Brum

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1423502

2,108 views
1 citation

Original Research

Published on 13 Nov 2024

Integration of metabolomics and transcriptomics to reveal anti-immunosuppression mechanism of Lycium barbarum polysaccharide

in Experimental Pharmacology and Drug Discovery

Jiandong Wang
Xue Zhang
Yi Wu
Qianfei Wei
Lingshan Yan
Youli Yu
Yanan Guo
Zhengqin Yu
Pan Wang
Xiaonan Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1486739

1,357 views