Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 11 Oct 2024

Tirzepatide, GIP(1-42) and GIP(1-30) display unique signaling profiles at two common GIP receptor variants, E354 and Q354

in Experimental Pharmacology and Drug Discovery

Tayla A. Rees
Benjamin J. Buttle
Zoe Tasma
Sung-Hyun Yang
Paul W. R. Harris
Christopher S. Walker

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1463313

3,166 views
3 citations

Original Research

Published on 10 Oct 2024

CircFOXO3 upregulation mediates the radioresistance of glioblastoma by affecting cellular metabolome

in Experimental Pharmacology and Drug Discovery

Hao Xu
Jin Xing
Lilin Cheng
Zhihan Wang
Liang Zhao
Li Ren
Shuai Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1479480

1,067 views

Original Research

Published on 09 Oct 2024

Combining mathematical modeling, in vitro data and clinical target expression to support bispecific antibody binding affinity selection: a case example with FAP-4-1BBL

in Experimental Pharmacology and Drug Discovery

Javier Sanchez
Christina Claus
Christine McIntyre
Tamara Tanos
Axel Boehnke
Lena E. Friberg
Siv Jönsson
Nicolas Frances

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1472662

2,204 views

Original Research

Published on 09 Oct 2024

Identification of high-affinity Monoamine oxidase B inhibitors for depression and Parkinson’s disease treatment: bioinformatic approach of drug repurposing

in Experimental Pharmacology and Drug Discovery

Moyad Shahwan
Pratibha Prasad
Dharmendra Kumar Yadav
Nojood Altwaijry
Mohd Shahnawaz Khan
Anas Shamsi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1422080

1,849 views

Original Research

Published on 09 Oct 2024

The NEDD4/FLRT2 axis regulates NSCLC cell stemness

in Experimental Pharmacology and Drug Discovery

Yuping Yang
Fei Yan
Ziwei Gao
Houke Li
Shengke Wen
Qi Li
Jiayuan Li
Na Huang
Wei Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1459978

1,597 views

Original Research

Published on 09 Oct 2024

The long non-coding RNA GAS5 contributes to the suppression of inflammatory responses by inhibiting NF-κB activity

in Experimental Pharmacology and Drug Discovery

Debora Curci
Biljana Stankovic
Nikola Kotur
Letizia Pugnetti
Vladimir Gasic
Maurizio Romano
Branka Zukic
Giuliana Decorti
Gabriele Stocco
Marianna Lucafò

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1448136

3,160 views
1 citation

Original Research

Published on 09 Oct 2024

Synthesis and characterization of activated carbon-supported magnetic nanocomposite (MNPs-OLAC) obtained from okra leaves as a nanocarrier for targeted delivery of morin hydrate

in Experimental Pharmacology and Drug Discovery

Cem Öziç
Erdal Ertaş
Mehmet Fırat Baran
Ayşe Baran
Elham Ahmadian
Aziz Eftekhari
Rovshan Khalilov
Elvin Aliyev
Mahmut Yıldıztekin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1482130

1,322 views
1 citation

Original Research

Published on 08 Oct 2024

FOXO1-mediated autophagy regulation by miR-223 in sepsis-induced immunosuppression

in Experimental Pharmacology and Drug Discovery

Guoan Xiang
Qi Li
Di Lian
Chengcheng Su
Xin Li
Shoulong Deng
Lixin Xie

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1469286

1,634 views
1 citation

Review

Published on 03 Oct 2024

Salvia miltiorrhiza in osteoporosis: a review of its phytochemistry, traditional clinical uses and preclinical studies (2014–2024)

in Experimental Pharmacology and Drug Discovery

Lili Wang
Shan Wang
Xuan Dai
Gaiyue Yue
Jiyuan Yin
Tianshu Xu
Hanfen Shi
Tianyuan Liu
Zhanhong Jia
Dieter Brömme

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1483431

4,036 views
1 citation

Original Research

Published on 01 Oct 2024

Xiaoyin-anshen formula alleviates psoriasis complicated by sleep disturbances by regulating melatonin, antioxidant enzymes, and pro-inflammatory cytokines in mice

in Experimental Pharmacology and Drug Discovery

Zebing Zhu
Qiang Yin
Xingwu Duan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1427985

2,124 views
1 citation

Original Research

Published on 01 Oct 2024

Drug repurposing to tackle parainfluenza 3 based on multi-similarities and network proximity analysis

in Experimental Pharmacology and Drug Discovery

Xinyue Chen
Bo Zhou
Xinyi Jiang
Huayu Zhong
Aijing You
Taiyan Zou
Chengcheng Zhou
Xiaoxiao Liu
Yonghong Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1428925

1,230 views

Original Research

Published on 01 Oct 2024

PBPK-based translation from preclinical species to humans for the full-size IgG therapeutic efalizumab

in Experimental Pharmacology and Drug Discovery

Maria Franz
Ravi Kumar Jairam
Lars Kuepfer
Nina Hanke

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1418870

2,545 views

Original Research

Published on 01 Oct 2024

KS18, a Mcl-1 inhibitor, improves the effectiveness of bortezomib and overcomes resistance in refractory multiple myeloma by triggering intrinsic apoptosis

in Experimental Pharmacology and Drug Discovery

Omar S. Al-Odat
Weam Othman Elbezanti
Krishne Gowda
Sandeep K. Srivastava
Shantu G. Amin
Subash C. Jonnalagadda
Tulin Budak-Alpdogan
Manoj K. Pandey

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1436786

2,050 views
2 citations

Original Research

Published on 27 Sep 2024

Integrating text mining with network models for successful target identification: in vitro validation in MASH-induced liver fibrosis

in Experimental Pharmacology and Drug Discovery

Jennifer Venhorst
Roeland Hanemaaijer
Remon Dulos
Martien P. M. Caspers
Karin Toet
Joline Attema
Christa de Ruiter
Gino Kalkman
Tanja Rouhani Rankouhi
Jelle C. B. C. de Jong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1442752

1,971 views
2 citations

Original Research

Published on 26 Sep 2024

Hyaluronic acid-solid lipid nano transporter serum preparation for enhancing topical tretinoin delivery: skin safety study and visual assessment of skin

in Experimental Pharmacology and Drug Discovery

Yasir Mehmood
Hira Shahid
Syeda Momena Rizvi
Usama Jamshaid
Numera Arshad
Mohammad Nur-e-Alam
Muhammad Delwar Hussain
Mohsin Kazi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1401594

1,996 views
1 citation

Review

Published on 26 Sep 2024

The onset and the development of cardiometabolic aging: an insight into the underlying mechanisms

in Experimental Pharmacology and Drug Discovery

Sulogna Sarkar
Vani S. Prasanna
Pamelika Das
Hiroshi Suzuki
Kazuya Fujihara
Satoru Kodama
Hirohito Sone
Remya Sreedhar
Ravichandiran Velayutham
Kenichi Watanabe

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1447890

2,845 views
1 citation