Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 15 Apr 2025

YX-112, a novel celastrol-derived PROTAC, inhibits the development of triple-negative breast cancer by targeting the degradation of multiple proteins

in Experimental Pharmacology and Drug Discovery

Yongxue Gu
Mengmeng Yang
Wenbin Wang
Lihua Li
Ying Ma
Wenshan Liu
Qiang Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1571135

1,107 views

Perspective

Published on 15 Apr 2025

Metabolic anomalies in vitiligo: a new frontier for drug repurposing strategies

in Experimental Pharmacology and Drug Discovery

Alessia Paganelli
Federica Papaccio
Mauro Picardo
Barbara Bellei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1546836

1,675 views

Original Research

Published on 14 Apr 2025

Integrating traditional omics and machine learning approaches to identify microbial biomarkers and therapeutic targets in pediatric inflammatory bowel disease

in Experimental Pharmacology and Drug Discovery

Lanlan Li
XuZai Deng
Shuge Wang
Tao Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1545392

755 views

Original Research

Published on 11 Apr 2025

Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma

in Experimental Pharmacology and Drug Discovery

Bin Liao
Pan Wang
Sheng Gong
Lu Zhao
Jie Liu
Nan Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1575332

950 views

Review

Published on 09 Apr 2025

Regulation of pyroptosis by natural products in ulcerative colitis: mechanisms and therapeutic potential

in Experimental Pharmacology and Drug Discovery

Xiaobei Lu
Yapeng Sun
Zhaoyi Zhang
Zhigang Sun
Shaohui Wang
Erping Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1573684

1,275 views

Original Research

Published on 09 Apr 2025

Danggui Shaoyao San ameliorates Alzheimer’s disease by regulating lipid metabolism and inhibiting neuronal ferroptosis through the AMPK/Sp1/ACSL4 signaling pathway

in Experimental Pharmacology and Drug Discovery

Kai Gong
Shuang Zhou
Li Xiao
Mengzhen Xu
Yuhe Zhou
Kaihui Lu
Xin Yu
Jiang Zhu
Chuanguo Liu
Qingjun Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1588375

1,125 views

Original Research

Published on 09 Apr 2025

Impacts of sulfate polysaccharide JCS1S2 on retinal neovascularization in oxygen-induced retinopathy rats

in Experimental Pharmacology and Drug Discovery

Yang Bai
Rui Wang
Can Jin
Lili Wang
Yun Tang
Han Wang
Kan Ding
Shanjun Cai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1499420

726 views

Original Research

Published on 09 Apr 2025

Discovery of CMNPD31124 as a novel marine-derived PKMYT1 inhibitor for pancreatic ductal adenocarcinoma therapy: computational and biological insights

in Experimental Pharmacology and Drug Discovery

Chaojie Huang
Ting Wang
Rui Chen
Yunyun Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1569765

881 views

Original Research

Published on 09 Apr 2025

A universal cannabinoid CB1 and CB2 receptor TR-FRET kinetic ligand-binding assay

in Experimental Pharmacology and Drug Discovery

Leire Borrega-Roman
Bradley L. Hoare
Miroslav Kosar
Roman C. Sarott
Kacper J. Patej
Jara Bouma
Morgan Scott-Dennis
Eline J. Koers
Thais Gazzi
Leonard Mach

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1469986

2,188 views

Original Research

Published on 08 Apr 2025

Identification of novel amides and alkaloids as putative inhibitors of dopamine transporter for schizophrenia using computer-aided virtual screening

in Experimental Pharmacology and Drug Discovery

Iqra Ahmad
Anam Tassawer
Muhammad Umer Khan
Muhammad Shehroz
Umar Nishan
Sheheryar Sheheryar
Hanna Dib
Mohamed A. O. Abdelfattah
Mohibullah Shah

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1509263

1,514 views

Hypothesis and Theory

Published on 08 Apr 2025

Quantification of signal amplification for receptors: the Kd/EC50 ratio of full agonists as a gain parameter

in Experimental Pharmacology and Drug Discovery

Peter Buchwald

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1541872

750 views

Original Research

Published on 08 Apr 2025

Molecular mechanisms of the anchang group prescription in treating radiation enteritis: network pharmacology analysis and experimental evidence

in Experimental Pharmacology and Drug Discovery

Wei Liang
Bo Li
Yuehong Sun
Dapeng Jia
Tingting Hu
Rujing Huang
Zhilong Liu
Huan Yang
Baocai Chen
Xiaoming Yin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1524925

1,365 views

Original Research

Published on 08 Apr 2025

Synergistic chemo-immunotherapy for osteosarcoma via a pH-responsive multi-component nanoparticle system

in Experimental Pharmacology and Drug Discovery

Dapeng Li
Yuanfan Li
Jie Cang
Xianwen Yan
Feipeng Wu
Xuan Sun
Wenchao Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1584245

1,071 views

Original Research

Published on 07 Apr 2025

Pharmacophore-based virtual screening and in silico investigations of small molecule library for discovery of human hepatic ketohexokinase inhibitors for the treatment of fructose metabolic disorders

in Experimental Pharmacology and Drug Discovery

Tilal Elsaman
Magdi Awadalla Mohamed
Abozer Y. Elderdery
Abdullah Alsrhani
Badr Alzahrani
Heba Bassiony Ghanem
Jeremy Mills
Musaed Rayzah
Nasser A. N. Alzerwi
Afnan Al-sultan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1531512

1,406 views

Original Research

Published on 07 Apr 2025

Ocular pharmacokinetics of intravitreal conbercept in a rabbit model following retinal scatter laser photocoagulation

in Experimental Pharmacology and Drug Discovery

Lanlan Chen
Hua Liu
Qingrong Zhang
Houbin Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1534048

521 views

Review

Published on 03 Apr 2025

Protein structure prediction via deep learning: an in-depth review

in Experimental Pharmacology and Drug Discovery

Yajie Meng
Zhuang Zhang
Chang Zhou
Xianfang Tang
Xinrong Hu
Geng Tian
Jialiang Yang
Yuhua Yao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1498662

1,961 views