Frontiers in Pharmacology | Gastrointestinal and Hepatic Pharmacology

Systematic Review

Published on 30 Apr 2025

Assessing the therapeutic potential of rutin in alleviating symptoms of inflammatory bowel disease: a meta-analysis

in Gastrointestinal and Hepatic Pharmacology

Zhenkai Zou
Fanglian Zhang
Zhigang Pan
Jinyao Xu
Xuanyi Li
Xiangjun Sun
Xufeng Wang
Feng Qin
Abulikemu Abulizi
Qian Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1539469

1,002 views

Original Research

Published on 30 Apr 2025

Albiflorin inhibits inflammation to improve liver fibrosis by targeting the CXCL12/CXCR4 axis in mice

in Gastrointestinal and Hepatic Pharmacology

Lingjie Meng
Huijing Lv
Anli Liu
Qian Cao
Xinyi Du
Chengjin Li
Qinggui Li
Qingqing Luo
Yi Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1577201

1,158 views

Original Research

Published on 30 Apr 2025

Resveratrol targeting MDM2/P53/PUMA axis to inhibit colonocyte apoptosis in DSS-induced ulcerative colitis mice

in Gastrointestinal and Hepatic Pharmacology

Rui Tang
Ling Jiang
Quan Ji
Pengyuan Kang
Yuan Liu
Pengyu Miao
Xiaofan Xu
Mingxi Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1572906

1,283 views

Original Research

Published on 29 Apr 2025

Proton pump inhibitors use and risk of type 2 diabetes mellitus: correlation analysis, prediction model construction, and key genes identification

in Gastrointestinal and Hepatic Pharmacology

Cuilv Liang
Yin Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1580090

1,338 views

Review

Published on 28 Apr 2025

Gastrointestinal injury in cardiopulmonary bypass: current insights and future directions

in Gastrointestinal and Hepatic Pharmacology

Qi-Long Mao
Zi-Hang Yu
Liang Nie
Fei-Xiang Wang
Yu-Hui Dong
Xiao-Fei Qi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1542995

548 views

Original Research

Published on 28 Apr 2025

Resveratrol and N-acetylcystein reduce hepatic steatosis but enhance initiation and progression of hepatocellular carcinoma by inhibiting GST-pi-MAPK axis in mice

in Gastrointestinal and Hepatic Pharmacology

Mi Zhang
Weigang Yuan
Chun Li
Chanyuan Chen
Xiang Liu
Zhilu Ma
Yifei Xiang
Guisha Chen
Chunxu Wang
Lei Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1574039

1,087 views

Review

Published on 28 Apr 2025

The role of hepatic sinusoidal microenvironment in NASH: pathogenesis, animal models, and therapeutic prospects

in Gastrointestinal and Hepatic Pharmacology

Wanying Tan
Jiangting Deng
Lingjun Qi
Zhenghuai Tan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1467950

678 views

Systematic Review

Published on 28 Apr 2025

Efficacy and safety of IL-23 p19 inhibitors in the treatment for inflammatory bowel disease: a systematic review and meta-analysis

in Gastrointestinal and Hepatic Pharmacology

Shuhan Wang
Hui Sun
Qian Wang
Han Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1490667

1,254 views

Original Research

Published on 25 Apr 2025

Macrophage PKM2 depletion ameliorates hepatic inflammation and acute liver injury in mice

in Gastrointestinal and Hepatic Pharmacology

Ziwei Kang
Ruoyan Xie
Yiming Cui
Zhiwei Chen
Jincheng Li
Jinyu Lv
Weijia Ye
Peixin Zhao
Keke Zhang
Jian Hong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1546045

1,089 views

Original Research

Published on 22 Apr 2025

Effect of propinox and pinaverium bromide on ex vivo colonic motor patterns and their synergistic effect with hyoscine butyl bromide

in Gastrointestinal and Hepatic Pharmacology

Sara Traserra
Luis Gerardo Alcalá-González
Claudia Barber
Stefania Landolfi
Carolina Malagelada
Robert Lange
Terence Appelqvist
Maura Corsetti
Marcel Jimenez

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1491123

927 views

Systematic Review

Published on 22 Apr 2025

The efficacy of aminosalicylates in acute radiation enteritis: a systematic review and meta-analysis

in Gastrointestinal and Hepatic Pharmacology

Zhendong Wu
Chuyan Ni
Zhen Ye
Zhongsheng Xia
Li Li
Zhong Yu
Song Tang
Ying Lin
Wa Zhong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1544981

818 views

Original Research

Published on 22 Apr 2025

Sodium aescinate promotes apoptosis of pancreatic stellate cells and alleviates pancreatic fibrosis by inhibiting the PI3K/Akt/FOXO1 signaling pathways

in Gastrointestinal and Hepatic Pharmacology

Qing-Yun Wang
Bai-Yan Xu
Yi Wang
Yan-Mei Lin
Lin-Fu Zheng
Gang Liu
Da-Zhou Li
Chuan-Shen Jiang
Wen Wang
Xiang-Peng Zeng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1554260

824 views

Review

Published on 22 Apr 2025

Targeting fibroblast growth factor (FGF)-21: a promising strategy for metabolic dysfunction-associated steatotic liver disease treatment

in Gastrointestinal and Hepatic Pharmacology

Xinyue Cui
Quanhao Sun
Haiqiang Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1510322

1,598 views

Original Research

Published on 16 Apr 2025

Inhibition of colorectal cancer cell growth by downregulation of M2-PK and reduction of aerobic glycolysis by clove active ingredients

in Gastrointestinal and Hepatic Pharmacology

Lin Liu
Gang Xing
Xiaoyi Guo
Hui Chen
Jian Li
Jian Wang
Yaling Li
Gang Liang
Minghua Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1552486

1,040 views

Review

Published on 15 Apr 2025

Understanding the complex role of exosomes in intestinal ischemia-reperfusion injury: from pathogenesis to protection

in Gastrointestinal and Hepatic Pharmacology

Qin Ye
Zi-Hang Yu
Liang Nie
Fei-Xiang Wang
Guo Mu
Bin Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1533628

626 views

Original Research

Published on 14 Apr 2025

Mirabegron induces selective changes in the faecal microbiota of HFHFr rats without altering bile acid composition

in Gastrointestinal and Hepatic Pharmacology

Roger Bentanachs
Lluïsa Miró
Patricia Ramírez-Carrasco
Rosa M. Sánchez
Manuel Bernabeu
Concepció Amat
Marta Alegret
Anna Pérez-Bosque
Núria Roglans
Juan C. Laguna

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1547749

1,158 views