Frontiers in Pharmacology | Predictive Toxicology

Original Research

Published on 29 Nov 2019

Development, Testing, Parameterization, and Calibration of a Human Physiologically Based Pharmacokinetic Model for the Plasticizer, Hexamoll® Diisononyl-Cyclohexane-1, 2-Dicarboxylate Using In Silico, In Vitro, and Human Biomonitoring Data

in Predictive Toxicology

Kevin McNally
Craig Sams
George Loizou

Frontiers in Pharmacology

doi 10.3389/fphar.2019.01394

4,028 views
11 citations

Original Research

Published on 26 Nov 2019

Additive Dose Response Models: Defining Synergy

in Predictive Toxicology

Simone Lederer
Tjeerd M. H. Dijkstra
Tom Heskes

Frontiers in Pharmacology

doi 10.3389/fphar.2019.01384

19,124 views
43 citations

Original Research

Published on 14 Nov 2019

Understanding the Bacterial Response to Mycotoxins: The Transcriptomic Analysis of Deoxynivalenol-Induced Changes in Devosia mutans 17-2-E-8

in Predictive Toxicology

Yousef I. Hassan
Jian Wei He
Dion Lepp
Ting Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2019.01098

3,742 views
10 citations

Case Report

Published on 08 Nov 2019

Hemolytic Anemia and Reactive Thrombocytosis Associated With Cefoperazone/Sulbactam

in Predictive Toxicology

Ling Zhou
Jianan Bao
Jingjing Ma

Frontiers in Pharmacology

doi 10.3389/fphar.2019.01342

8,633 views
8 citations

Review

Published on 06 Nov 2019

Phthalate-Induced Fetal Leydig Cell Dysfunction Mediates Male Reproductive Tract Anomalies

in Predictive Toxicology

Yiyan Wang
Chaobo Ni
Xiaoheng Li
Zhenkun Lin
Qiqi Zhu
Linxi Li
Ren-Shan Ge

Frontiers in Pharmacology

doi 10.3389/fphar.2019.01309

6,203 views
41 citations

Methods

Published on 06 Nov 2019

Unpredictable Nanoparticle Retention in Commonly Used Plastic Syringes Introduces Dosage Uncertainties That May Compromise the Accuracy of Nanomedicine and Nanotoxicology Studies

in Predictive Toxicology

Uwe Holzwarth
Unai Cossío
Jordi Llop
Wolfgang G. Kreyling

Frontiers in Pharmacology

doi 10.3389/fphar.2019.01293

4,590 views
10 citations

Correction

Published on 24 Oct 2019

Corrigendum: Interference With Coagulation Cascade as a Novel Approach to Counteract Cisplatin-Induced Acute Tubular Necrosis; an Experimental Study in Rats

in Predictive Toxicology

Mohamed G. Ewees
Basim A. S. Messiha
Ali A. Abo-Saif
Asmaa M. A. Bayoumi
Mohamed S. Abdel-Bakky

Frontiers in Pharmacology

doi 10.3389/fphar.2019.01259

1,307 views
2 citations

Original Research

Published on 18 Oct 2019

Zearalenone and ß-Zearalenol But Not Their Glucosides Inhibit Heat Shock Protein 90 ATPase Activity

in Predictive Toxicology

Juan Antonio Torres Acosta
Herbert Michlmayr
Mehrdad Shams
Wolfgang Schweiger
Gerlinde Wiesenberger
Rudolf Mitterbauer
Ulrike Werner
David Merz
Marie-Theres Hauser
Christian Hametner

Frontiers in Pharmacology

doi 10.3389/fphar.2019.01160

4,291 views
7 citations

Original Research

Published on 17 Oct 2019

Construction and Analysis of circRNA-miRNA-mRNA Molecular Regulatory Networks During Herba Gelsemium elegans Intoxication

in Predictive Toxicology

Yinghao Wang
Shuisheng Wu
Ce Yang
Hanyun Gao
Hongmin Yu
Xuehua Lu
Shugang Yuan

Frontiers in Pharmacology

doi 10.3389/fphar.2019.01217

3,447 views
6 citations

Original Research

Published on 16 Oct 2019

Toxicity Study of 28-Day Subcutaneous Injection of Arctigenin in Beagle Dogs

in Predictive Toxicology

Jie Li
Yun-gang Lv
Li-hong Pan
Fang-fang Yao
Tao Peng
Yu-jun Tan
Gui-Min Zhang
Zhong Liu
Jing-chun Yao
Yu-shan Ren

Frontiers in Pharmacology

doi 10.3389/fphar.2019.01218

6,234 views
4 citations

Original Research

Published on 11 Oct 2019

Akt Regulated Phosphorylation of GSK-3β/Cyclin D1, p21 and p27 Contributes to Cell Proliferation Through Cell Cycle Progression From G1 to S/G2M Phase in Low-Dose Arsenite Exposed HaCat Cells

in Predictive Toxicology

Yao Chen
Xudan Liu
Huanhuan Wang
Shiyi Liu
Nannan Hu
Xin Li

Frontiers in Pharmacology

doi 10.3389/fphar.2019.01176

5,418 views
47 citations

Original Research

Published on 08 Oct 2019

Cardiotoxicity of Intravenously Administered CdSe/ZnS Quantum Dots in BALB/c Mice

in Predictive Toxicology

Li Li
Jinglin Tian
Xiaomei Wang
Gaixia Xu
Wenxiao Jiang
Zhiwen Yang
Dongmeng Liu
Guimiao Lin

Frontiers in Pharmacology

doi 10.3389/fphar.2019.01179

3,681 views
20 citations

Case Report

Published on 11 Sep 2019

Acute Liver Failure in a Patient Treated With Metamizole

in Predictive Toxicology

Philipp Krisai
Deborah Rudin
David Grünig
Kathrin Scherer
Werner Pichler
Luigi Terracciano
Stephan Krähenbühl

Frontiers in Pharmacology

doi 10.3389/fphar.2019.00996

5,702 views
15 citations

Original Research

Published on 26 Jul 2019

Reliable Target Prediction of Bioactive Molecules Based on Chemical Similarity Without Employing Statistical Methods

in Predictive Toxicology

Abed Forouzesh
Sadegh Samadi Foroushani
Fatemeh Forouzesh
Eskandar Zand

Frontiers in Pharmacology

doi 10.3389/fphar.2019.00835

13,532 views
20 citations

Original Research

Published on 19 Jul 2019

Lipidomic Profiling Reveals Disruption of Lipid Metabolism in Valproic Acid-Induced Hepatotoxicity

in Predictive Toxicology

Shansen Xu
Yanan Chen
Yiyi Ma
Ting Liu
Mingming Zhao
Zhanyou Wang
Limei Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2019.00819

8,517 views
33 citations

Original Research

Published on 12 Jul 2019

Prostaglandin E2 Signals Through E Prostanoid Receptor 2 to Inhibit Mitochondrial Superoxide Formation and the Ensuing Downstream Cytotoxic and Genotoxic Effects Induced by Arsenite

in Predictive Toxicology

Liana Cerioni
Andrea Guidarelli
Mara Fiorani
Orazio Cantoni

Frontiers in Pharmacology

doi 10.3389/fphar.2019.00781

2,136 views