Frontiers in Pharmacology | Predictive Toxicology

Original Research

Published on 03 Oct 2024

Development and validation of PBPK models for genistein and daidzein for use in a next-generation risk assessment

in Predictive Toxicology

A. Najjar
D. Lange
C. Géniès
J. Kuehnl
A. Zifle
C. Jacques
E. Fabian
N. Hewitt
A. Schepky

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1421650

3,819 views
5 citations

Review

Published on 24 Sep 2024

Apoptosis, autophagy, ferroptosis, and pyroptosis in cisplatin-induced ototoxicity and protective agents

in Predictive Toxicology

Dingyuan Dai
Chao Chen
Chen Lu
Yu Guo
Qi Li
Chen Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1430469

6,016 views
9 citations

Original Research

Published on 24 Sep 2024

Potential mechanisms underlying podophyllotoxin-induced cardiotoxicity in male rats: toxicological evidence chain (TEC) concept

in Predictive Toxicology

Kaiyue Ma
Lu Sun
Chunxue Jia
Hongqian Kui
Jiaqi Xie
Shidan Zang
Shixin Huang
Jinfeng Que
Chuanxin Liu
Jianmei Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1378758

2,953 views
3 citations

Original Research

Published on 28 Aug 2024

A real-world pharmacovigilance study of KRAS G12C mutation inhibitors based on the food and drug administration adverse event reporting system

in Predictive Toxicology

Lisha Wu
Maosheng Xu
Xueqin Li
Dilinuer Aierken
Jinxiu Yu
Tao Qin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1418469

4,221 views
3 citations

Original Research

Published on 21 Aug 2024

Comprehensive hepatotoxicity prediction: ensemble model integrating machine learning and deep learning

in Predictive Toxicology

Muhammad Zafar Irshad Khan
Jia-Nan Ren
Cheng Cao
Hong-Yu-Xiang Ye
Hao Wang
Ya-Min Guo
Jin-Rong Yang
Jian-Zhong Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1441587

4,168 views
10 citations

Original Research

Published on 14 Aug 2024

Predicting non-chemotherapy drug-induced agranulocytosis toxicity through ensemble machine learning approaches

in Predictive Toxicology

Xiaojie Huang
Xiaochun Xie
Shaokai Huang
Shanshan Wu
Lina Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1431941

2,518 views
3 citations

Original Research

Published on 09 Aug 2024

Assessing the immunogenicity risk of salmon calcitonin peptide impurities using in silico and in vitro methods

in Predictive Toxicology

Brian J. Roberts
Aimee E. Mattei
Kristina E. Howard
James L. Weaver
Hao Liu
Sandra Lelias
William D. Martin
Daniela Verthelyi
Eric Pang
Katie J. Edwards

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1363139

6,406 views
5 citations

Original Research

Published on 24 Jul 2024

Treatment of an accident of imidacloprid poisoning

in Predictive Toxicology

Mei Zeng
Mengdi Shi
Xiangdong Jian
Laidong Dong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1421437

7,877 views
2 citations

Original Research

Published on 17 Jul 2024

Quantum chemical calculations of nitrosamine activation and deactivation pathways for carcinogenicity risk assessment

in Predictive Toxicology

Andreas H. Göller
Sandra Johanssen
Adam Zalewski
Verena Ziegler

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1415266

6,926 views
3 citations

Original Research

Published on 17 Jul 2024

Analysis of eplerenone in the FDA adverse event reporting system (FAERS) database: a focus on overall patient population and gender-specific subgroups

in Predictive Toxicology

Xin Guan
Yusi Yang
Xinru Li
Yue Feng
Jizhen Li
Xuewen Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1417951

4,807 views
6 citations

Case Report

Published on 17 Jul 2024

Fatal hyperpyrexia caused by xylazine: a case report

in Predictive Toxicology

Ping Dai
Yanqing Chen
Xianqin Luo
Zhiqiang Zhou
Mengdi Shi
Aerbusili Genjiafu
Xiangdong Jian

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1437960

1,935 views
4 citations

Original Research

Published on 12 Jul 2024

Protective effect of naringenin on cadmium chloride-induced renal injury via alleviating oxidative stress, endoplasmic reticulum stress, and autophagy in chickens

in Predictive Toxicology

Yaning Shi
Zhixin Gao
Bing Xu
Junbing Mao
Yue Wang
Zongping Liu
Jicang Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1440877

3,093 views
5 citations

Original Research

Published on 20 Jun 2024

Toxicological safety assessment of a water extract of Lithocarpus litseifolius by a 90-day repeated oral toxicity study in rats

in Predictive Toxicology

Jinfeng Ma
Yujia Wei
Jingfeng Sun
Fang Tan
Penghe Liu
Guangqiu Qin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1385550

1,694 views
2 citations

Original Research

Published on 19 Jun 2024

Assessing genotoxic effects of chemotherapy agents by a robust in vitro assay based on mass spectrometric quantification of γ-H2AX in HepG2 cells

in Predictive Toxicology

Minmin Qu
Jia Chen
Bin Xu
Qinyun Shi
Shujing Zhao
Zhaoxia Wang
Zhi Li
Bo Ma
Hua Xu
Qinong Ye

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1356753

3,408 views

Original Research

Published on 19 Jun 2024

Next-generation risk assessment read-across case study: application of a 10-step framework to derive a safe concentration of daidzein in a body lotion

in Predictive Toxicology

Abdulkarim Najjar
Jochen Kühnl
Daniela Lange
Camille Géniès
Carine Jacques
Eric Fabian
Anne Zifle
Nicola J. Hewitt
Andreas Schepky

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1421601

5,495 views
11 citations

Review

Published on 18 Jun 2024

A web-based scoping review assessing the influence of smoking and smoking cessation on antidiabetic drug meabolism: implications for medication efficacy

in Predictive Toxicology

Carlo Maria Bellanca
Egle Augello
Giulia Di Benedetto
Chiara Burgaletto
Anna Flavia Cantone
Giuseppina Cantarella
Renato Bernardini
Riccardo Polosa
the DiaSmokeFree Working Group
Agostino Di Ciaula

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1406860

8,591 views
5 citations

Original Research

Published on 13 Jun 2024

Involvement of autophagy in mesaconitine-induced neurotoxicity in HT22 cells revealed through integrated transcriptomic, proteomic, and m6A epitranscriptomic profiling

in Predictive Toxicology

Xiaohuang Lin
Jian Zhang
Zekai Wu
Yuan Shi
Mengting Chen
Maodong Li
Hong Hu
Kun Tian
Xiaoqi Lv
Chutao Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1393717

4,514 views
9 citations

Original Research

Published on 17 May 2024

Upregulation of GOLPH3 mediated by Bisphenol a promotes colorectal cancer proliferation and migration: evidence based on integrated analysis

in Predictive Toxicology

Lihua Chen
Shaojian Chen
Yachen Li
Yi Qiu
Xiaojing Chen
Yuze Wu
Xian Deng
Mingliang Chen
Chunxiao Wang
Zhongshi Hong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1337883

3,449 views
3 citations

Original Research

Published on 09 May 2024

Delineation of renal protein profiles in aristolochic acid I-induced nephrotoxicity in mice by label-free quantitative proteomics

in Predictive Toxicology

Xinhui Liu
Shanshan Wu
Yu Peng
Liwen Gao
Xi Huang
Ruyu Deng
Jiandong Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1341854

2,667 views
1 citation

Original Research

Published on 10 Apr 2024

Effects of ranolazine on the arrhythmic substrate in hypertrophic cardiomyopathy

in Predictive Toxicology

James A. Coleman
Ruben Doste
Matteo Beltrami
Alessia Argirò
Raffaele Coppini
Iacopo Olivotto
Betty Raman
Alfonso Bueno-Orovio

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1379236

3,327 views
10 citations

Original Research

Published on 10 Apr 2024

Exploiting the predictive power of educated spheroids to detect immune-mediated idiosyncratic drug-induced liver injury: the case of troglitazone

in Predictive Toxicology

Salomé Roux
Sara Cherradi
Hong Tuan Duong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1378371

3,654 views
5 citations

Case Report

Published on 27 Mar 2024

Case report: Paralytic ileus resulted from nirmatrelvir/ritonavir-tacrolimus drug-drug interaction in a systemic lupus erythematosus patient with COVID-19

in Predictive Toxicology

Wei Zhang
Xingguo Zhang
Jinming Han
Wen Zhang
Jiarui Xu
Xin Zhang
Hongjun Bian
Chong Meng
Deya Shang
Yi Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1389187

2,840 views
1 citation

Original Research

Published on 19 Mar 2024

Safety assessment of Acori Tatarinowii Rhizoma: acute and subacute oral toxicity

in Predictive Toxicology

Jia Liu
Xin Ping
Shu-jie Sun
Jiali Yang
Ye Lu
Lin Pei

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1377876

3,472 views
6 citations

Review

Published on 19 Mar 2024

Emerging insights into the impacts of heavy metals exposure on health, reproductive and productive performance of livestock

in Predictive Toxicology

Ali Afzal
Naima Mahreen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1375137

18,639 views
64 citations

490 articles

articles

Development and validation of PBPK models for genistein and daidzein for use in a next-generation risk assessment

Apoptosis, autophagy, ferroptosis, and pyroptosis in cisplatin-induced ototoxicity and protective agents

Potential mechanisms underlying podophyllotoxin-induced cardiotoxicity in male rats: toxicological evidence chain (TEC) concept

A real-world pharmacovigilance study of KRAS G12C mutation inhibitors based on the food and drug administration adverse event reporting system

Comprehensive hepatotoxicity prediction: ensemble model integrating machine learning and deep learning

Predicting non-chemotherapy drug-induced agranulocytosis toxicity through ensemble machine learning approaches

Assessing the immunogenicity risk of salmon calcitonin peptide impurities using in silico and in vitro methods

Treatment of an accident of imidacloprid poisoning

Quantum chemical calculations of nitrosamine activation and deactivation pathways for carcinogenicity risk assessment

Analysis of eplerenone in the FDA adverse event reporting system (FAERS) database: a focus on overall patient population and gender-specific subgroups

Fatal hyperpyrexia caused by xylazine: a case report

Protective effect of naringenin on cadmium chloride-induced renal injury via alleviating oxidative stress, endoplasmic reticulum stress, and autophagy in chickens

Toxicological safety assessment of a water extract of Lithocarpus litseifolius by a 90-day repeated oral toxicity study in rats

Assessing genotoxic effects of chemotherapy agents by a robust in vitro assay based on mass spectrometric quantification of γ-H2AX in HepG2 cells

Next-generation risk assessment read-across case study: application of a 10-step framework to derive a safe concentration of daidzein in a body lotion

A web-based scoping review assessing the influence of smoking and smoking cessation on antidiabetic drug meabolism: implications for medication efficacy

Involvement of autophagy in mesaconitine-induced neurotoxicity in HT22 cells revealed through integrated transcriptomic, proteomic, and m6A epitranscriptomic profiling

Upregulation of GOLPH3 mediated by Bisphenol a promotes colorectal cancer proliferation and migration: evidence based on integrated analysis

Delineation of renal protein profiles in aristolochic acid I-induced nephrotoxicity in mice by label-free quantitative proteomics

Effects of ranolazine on the arrhythmic substrate in hypertrophic cardiomyopathy

Exploiting the predictive power of educated spheroids to detect immune-mediated idiosyncratic drug-induced liver injury: the case of troglitazone

Case report: Paralytic ileus resulted from nirmatrelvir/ritonavir-tacrolimus drug-drug interaction in a systemic lupus erythematosus patient with COVID-19

Safety assessment of Acori Tatarinowii Rhizoma: acute and subacute oral toxicity

Emerging insights into the impacts of heavy metals exposure on health, reproductive and productive performance of livestock