Frontiers in Pharmacology | Translational Pharmacology

Original Research

Published on 10 May 2024

In vivo imaging system (IVIS) therapeutic assessment of tyrosine kinase inhibitor-loaded gold nanocarriers for acute myeloid leukemia: a pilot study

in Translational Pharmacology

Raluca-Andrada Munteanu
Adrian Bogdan Tigu
Richard Feder
Andra-Sorina Tatar
Diana Gulei
Ciprian Tomuleasa
Sanda Boca

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1382399

4,092 views
3 citations

Editorial

Published on 19 Apr 2024

Editorial: Use of Artificial Intelligence to evaluate drug-related behavioral changes in rodents

in Translational Pharmacology

Victor Fattori
Sara González-Rodríguez
Rafael González-Cano

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1396454

1,985 views

Original Research

Published on 17 Apr 2024

A physiologically based pharmacokinetic/pharmacodynamic model to determine dosage regimens and withdrawal intervals of aditoprim against Streptococcus suis

in Translational Pharmacology

Kun Mi
Lei Sun
Lan Zhang
Aoran Tang
Xiaoyuan Tian
Yixuan Hou
Lingling Sun
Lingli Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1378034

2,554 views
6 citations

Methods

Published on 12 Apr 2024

Early, precise, and safe clinical evaluation of the pharmacodynamic effects of novel agents in the intact human tumor microenvironment

in Translational Pharmacology

Kenneth R. Gundle
Karthik Rajasekaran
Jeffrey Houlton
Gary B. Deutsch
Thomas J. Ow
Robert G. Maki
John Pang
Cherie-Ann O. Nathan
Daniel Clayburgh
Jason G. Newman

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1367581

4,265 views
2 citations

Original Research

Published on 05 Apr 2024

Lipophilic analogues of D-cysteine prevent and reverse physical dependence to fentanyl in male rats

in Translational Pharmacology

James N. Bates
Paulina M. Getsy
Gregory A. Coffee
Santhosh M. Baby
Peter M. MacFarlane
Yee-Hsee Hsieh
Zackery T. Knauss
Jason A. Bubier
Devin Mueller
Stephen J. Lewis

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1336440

3,239 views
4 citations

Mini Review

Published on 25 Mar 2024

Impact of bariatric surgery on cytochrome P 450 enzyme activity

in Translational Pharmacology

Anna Pham
Patrick Chan
Angela Mercado
Jeffrey Wang
Zhijun Wang
Hajer Ibrahim
Hyma Gogineni
Ying Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1372950

2,432 views
2 citations

Mini Review

Published on 18 Mar 2024

The application of Phase 0 and microtracer approaches in early clinical development: past, present, and future

in Translational Pharmacology

A. F. Roffel
E.-J. van Hoogdalem

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1369079

4,837 views
4 citations

Original Research

Published on 07 Mar 2024

Assessing the relative contribution of CYP3A-and P-gp-mediated pathways to the overall disposition and drug-drug interaction of dabigatran etexilate using a comprehensive mechanistic physiological-based pharmacokinetic model

in Translational Pharmacology

Udomsak Udomnilobol
Wilasinee Dunkoksung
Watchara Sakares
Suree Jianmongkol
Thomayant Prueksaritanont

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1356273

3,200 views
4 citations

Review

Published on 04 Mar 2024

Pathophysiological aspects of transferrin-A potential nano-based drug delivery signaling molecule in therapeutic target for varied diseases

in Translational Pharmacology

Chang Li
Liya Zhou
Xunzhe Yin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1342181

7,367 views
19 citations

Original Research

Published on 04 Mar 2024

Synthesis, biological and computational evaluation of novel cyanomethyl vinyl ether derivatives

in Translational Pharmacology

Endika Martín-Encinas
María Fuertes
Samuel Delgado-Hernández
Fernando García-Tellado
David Tejedor
Concepción Alonso

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1344042

2,453 views
1 citation

Original Research

Published on 01 Mar 2024

Evaluation of binding mechanism of dietary phytochemical, capsaicin, with human transferrin: targeting neurodegenerative diseases therapeutics

in Translational Pharmacology

Mohammed Alrouji
Fahad A. Alhumaydhi
Kumar Venkatesan
Sharaf E. Sharaf
Moyad Shahwan
Anas Shamsi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1348128

2,781 views
4 citations

Original Research

Published on 23 Feb 2024

Quantification of stimulus-evoked tactile allodynia in free moving mice by the chainmail sensitivity test

in Translational Pharmacology

Yildirim Ozdemir
Kazuo Nakamoto
Bruno Boivin
Daniel Bullock
Nick A. Andrews
Rafael González-Cano
Michael Costigan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1352464

3,572 views
1 citation

Perspective

Published on 22 Feb 2024

Exploiting the damaging effects of ROS for therapeutic use by deactivating cell-free chromatin: the alchemy of resveratrol and copper

in Translational Pharmacology

Indraneel Mittra

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1345786

4,118 views
9 citations

Review

Published on 13 Feb 2024

Exploring the efficacy and safety of Ambroxol in Gaucher disease: an overview of clinical studies

in Translational Pharmacology

Feda E. Mohamed
Fatma Al-Jasmi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1335058

11,725 views
10 citations

Review

Published on 08 Feb 2024

A comprehensive review of the literature on CD10: its function, clinical application, and prospects

in Translational Pharmacology

Shudong Wang
Yinghui Xiao
Xingna An
Ling Luo
Kejian Gong
Dehai Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1336310

11,853 views
16 citations

Review

Published on 08 Feb 2024

Update on the advances and challenges in bioequivalence testing methods for complex topical generic products

in Translational Pharmacology

Nedaa Alomari
Waleed Alhussaini

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1330712

6,055 views
7 citations

Original Research

Published on 07 Feb 2024

Prediction of drug–disease associations based on reinforcement symmetric metric learning and graph convolution network

in Translational Pharmacology

Huimin Luo
Chunli Zhu
Jianlin Wang
Ge Zhang
Junwei Luo
Chaokun Yan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1337764

3,300 views
8 citations

Clinical Trial

Published on 07 Feb 2024

Hexasodium fytate exposure-response correlations in a randomized, placebo-controlled study of patients on dialysis with cardiovascular calcification

in Translational Pharmacology

Joan Perelló
Joan Alberti
Juan Vicente Torres
Miguel D. Ferrer
M. Mar Perez
Firas Bassissi
Alex Gold
Paolo Raggi
Glenn M. Chertow
Carolina Salcedo

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1325186

2,410 views
1 citation

Original Research

Published on 06 Feb 2024

Prevalence and clinical significance of potential drug-drug interactions among lung transplant patients

in Translational Pharmacology

Jiali Zhang
Danyi Ma
Meng Chen
Yanting Hu
Xveying Chen
Jingyu Chen
Man Huang
Haibin Dai

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1308260

3,173 views
6 citations

Original Research

Published on 26 Jan 2024

Surgical procedure of intratympanic injection and inner ear pharmacokinetics simulation in domestic pigs

in Translational Pharmacology

Adele Moatti
Shannon Connard
Novietta De Britto
William A. Dunn
Srishti Rastogi
Mani Rai
Lauren V. Schnabel
Frances S. Ligler
Kendall A. Hutson
Douglas C. Fitzpatrick

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1348172

5,307 views
7 citations

Clinical Trial

Published on 25 Jan 2024

Effect of dexmedetomidine on postoperative nausea and vomiting in female patients undergoing radical thoracoscopic lung cancer resection

in Translational Pharmacology

Haipeng Zhu
Shichao Wang
Ruohan Wang
Bing Li
Jiaqiang Zhang
Wei Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1353620

2,696 views
9 citations

Clinical Trial

Published on 19 Jan 2024

Towards a better detection of patients at-risk of linezolid toxicity in clinical practice: a prospective study in three Belgian hospital centers

in Translational Pharmacology

Hélène Thirot
David Fage
Antonia Leonhardt
Philippe Clevenbergh
Tatiana Besse-Hammer
Jean Cyr Yombi
Olivier Cornu
Caroline Briquet
Maya Hites
Frédérique Jacobs

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1310309

4,889 views
12 citations

Review

Published on 11 Jan 2024

The potential influence of melatonin on mitochondrial quality control: a review

in Translational Pharmacology

Xudan Lei
Zhenni Xu
Lingxiao Huang
Yujun Huang
Siyu Tu
Lu Xu
Dengqun Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1332567

10,807 views
17 citations

Original Research

Published on 10 Jan 2024

Population pharmacokinetic modeling of ilaprazole in healthy subjects and patients with duodenal ulcer in China

in Translational Pharmacology

Mengyang Yu
Shupeng Liu
Xiaofei Wu
Hongyun Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1306222

3,253 views
1 citation

1,083 articles

articles

In vivo imaging system (IVIS) therapeutic assessment of tyrosine kinase inhibitor-loaded gold nanocarriers for acute myeloid leukemia: a pilot study

Editorial: Use of Artificial Intelligence to evaluate drug-related behavioral changes in rodents

A physiologically based pharmacokinetic/pharmacodynamic model to determine dosage regimens and withdrawal intervals of aditoprim against Streptococcus suis

Early, precise, and safe clinical evaluation of the pharmacodynamic effects of novel agents in the intact human tumor microenvironment

Lipophilic analogues of D-cysteine prevent and reverse physical dependence to fentanyl in male rats

Impact of bariatric surgery on cytochrome P 450 enzyme activity

The application of Phase 0 and microtracer approaches in early clinical development: past, present, and future

Assessing the relative contribution of CYP3A-and P-gp-mediated pathways to the overall disposition and drug-drug interaction of dabigatran etexilate using a comprehensive mechanistic physiological-based pharmacokinetic model

Pathophysiological aspects of transferrin-A potential nano-based drug delivery signaling molecule in therapeutic target for varied diseases

Synthesis, biological and computational evaluation of novel cyanomethyl vinyl ether derivatives

Evaluation of binding mechanism of dietary phytochemical, capsaicin, with human transferrin: targeting neurodegenerative diseases therapeutics

Quantification of stimulus-evoked tactile allodynia in free moving mice by the chainmail sensitivity test

Exploiting the damaging effects of ROS for therapeutic use by deactivating cell-free chromatin: the alchemy of resveratrol and copper

Exploring the efficacy and safety of Ambroxol in Gaucher disease: an overview of clinical studies

A comprehensive review of the literature on CD10: its function, clinical application, and prospects

Update on the advances and challenges in bioequivalence testing methods for complex topical generic products

Prediction of drug–disease associations based on reinforcement symmetric metric learning and graph convolution network

Hexasodium fytate exposure-response correlations in a randomized, placebo-controlled study of patients on dialysis with cardiovascular calcification

Prevalence and clinical significance of potential drug-drug interactions among lung transplant patients

Surgical procedure of intratympanic injection and inner ear pharmacokinetics simulation in domestic pigs

Effect of dexmedetomidine on postoperative nausea and vomiting in female patients undergoing radical thoracoscopic lung cancer resection

Towards a better detection of patients at-risk of linezolid toxicity in clinical practice: a prospective study in three Belgian hospital centers

The potential influence of melatonin on mitochondrial quality control: a review

Population pharmacokinetic modeling of ilaprazole in healthy subjects and patients with duodenal ulcer in China