Frontiers in Physiology | Gastrointestinal Sciences

Original Research

Published on 06 Feb 2026

Proinflammatory cytokines modify Ca2+ signaling and induce an apoptotic lipidome in murine small intestinal organoids

in Gastrointestinal Sciences

Svenja Mareike Pauer
Alina Schindler
Parviz Ghezellou
Bernhard Spengler
Martin Diener
Jasmin Ballout

Frontiers in Physiology

doi 10.3389/fphys.2026.1738447

379 views

Original Research

Accepted on 02 Feb 2026

Endoscopic Excision for Internal and Mixed Hemorrhoids: A Retrospective Case Series of Short-Term Outcomes

in Gastrointestinal Sciences

Qi Xu
Bingfeng Qiu
Tangzhou Xu
Dandan Zhuang
Junhan Qu

Frontiers in Physiology

Review

Accepted on 02 Feb 2026

The role of bile acid-activated receptor TGR5 in inflammation and liver diseases

in Gastrointestinal Sciences

Hongyan Xiang
Huanyu Xiang
Shuyun Wang
Peiyu Wu
Zhidan Luo
Jie Zhang

Frontiers in Physiology

Correction

Published on 30 Jan 2026

Correction: Hypoxia promotes gastric cancer malignancy partly through the HIF-1α dependent transcriptional activation of the long non-coding RNA GAPLINC

in Gastrointestinal Sciences

Lei Liu
Xihe Zhao
Huawei Zou
Rubing Bai
Keyu Yang
Zhong Tian

Frontiers in Physiology

doi 10.3389/fphys.2026.1785431

273 views

Original Research

Accepted on 28 Jan 2026

Effect of enteral nutrition support combined with prone position mechanical ventilation on respiratory function, nutritional status, and inflammatory response in patients with severe pneumonia

in Gastrointestinal Sciences

Li Xu
Ling Xie
Huijuan Wang

Frontiers in Physiology

Original Research

Published on 13 Jan 2026

Clinical application of capsule endoscopy in children with small bowel disease in Wuhan, China

in Gastrointestinal Sciences

Pingping Xu
Dan Luo
Baoxiang Wang
Yingru Liu
Siyue Tang
Shan Guo
Zhi Yu
Leyong Zheng
Jie Feng
Huifen Huang

Frontiers in Physiology

doi 10.3389/fphys.2025.1714118

815 views

Original Research

Accepted on 07 Jan 2026

Prolactin and oxytocin as modulators of intestinal contractility and glucose uptake

in Gastrointestinal Sciences

Perla Alejandra Figueroa-Carrasco
Aída Jimena Velarde-Salcedo
Carmen Gonzalez

Frontiers in Physiology

401 views

Original Research

Published on 05 Jan 2026

Effects of GLP-1 and GIP on cholinergic-induced contractility in isolated jejunal muscle from obese patients with and without type 2 diabetes mellitus

in Gastrointestinal Sciences

Mantas Malinauskas
Darius Stukas
Kristina Rysevaite-Kyguoliene
Rita Gudaityte
Limas Kupčinskas
Anna Casselbrant
Lina Jankauskaite
Almantas Maleckas

Frontiers in Physiology

doi 10.3389/fphys.2025.1734360

1,079 views

Review

Published on 19 Dec 2025

Potassium-competitive acid blockers and advances in the management of patients with acid-related diseases: a narrative review

in Gastrointestinal Sciences

Xinwei Qiao
Peng Li

Frontiers in Physiology

doi 10.3389/fphys.2025.1655102

3,382 views

Systematic Review

Published on 26 Nov 2025

Association between body mass index at different levels and risk of gastroesophageal reflux disease: a systematic review with dose-response meta-analysis

in Gastrointestinal Sciences

Mao Yiqing
Zhang Yangyang
Hu Lanshuo
Zhang Wenhao
An Yixin
Zhao Yingpan
Tang Xudong

Frontiers in Physiology

doi 10.3389/fphys.2025.1675457

1,419 views

Review

Published on 12 Nov 2025

Efficacy of multimodal rehabilitation strategies on gastrointestinal function recovery in postoperative aortic dissection patients: a narrative review

in Gastrointestinal Sciences

Jing-Hua Xiao
Jing-Xue Wei
Zi-Ting Bi
Lang Huang
Yuan-Hong Dai
Yun-Shan Zhang

Frontiers in Physiology

doi 10.3389/fphys.2025.1671629

1,281 views

Mini Review

Published on 30 Oct 2025

The gut microbiome and gastrointestinal cancers: mechanisms, biomarkers and therapeutic opportunities

in Gastrointestinal Sciences

Sarbjeet Kaur Makkar
Kumar S. Bishnupuri

Frontiers in Physiology

doi 10.3389/fphys.2025.1676796

3,093 views

Original Research

Published on 29 Oct 2025

Physical capacity modulates intestinal barrier dysfunction in functional disorders: phenotype-specific patterns in fibromyalgia and irritable bowel syndrome

in Gastrointestinal Sciences

Francesco Russo
Antonella Bianco
Laura Prospero
Gaetana Laselva
Marco Grasso
Benedetta D’Attoma
Nicola Verrelli
Antonia Ignazzi
Isabella Franco
Francesco Goscilo

Frontiers in Physiology

doi 10.3389/fphys.2025.1695163

1,540 views

Original Research

Published on 27 Oct 2025

Machine learning-based algorithms for the prediction of 90-day survival in patients with liver failure receiving artificial liver therapy

in Gastrointestinal Sciences

Bo Deng
Chengzhi Bai
Huaqian Xu
Xue Zhang
Ying Deng

Frontiers in Physiology

doi 10.3389/fphys.2025.1687860

1,247 views

Brief Research Report

Published on 10 Oct 2025

Identifying key features for determining the patterns of patients with functional dyspepsia using machine learning

in Gastrointestinal Sciences

Heeyoung Moon
Da-Eun Yoon
Junsuk Kim
Younkuk Choi
Heekyung Kim
In-Seon Lee
Younbyoung Chae

Frontiers in Physiology

doi 10.3389/fphys.2025.1658866

2,320 views

Original Research

Published on 09 Oct 2025

Development of a convolutional neural network-based AI-assisted multi-task colonoscopy withdrawal quality control system (with video)

in Gastrointestinal Sciences

Jian Chen
Menglin Zhu
Zhijia Shen
Kaijian Xia
Xiaodan Xu
Ganhong Wang

Frontiers in Physiology

doi 10.3389/fphys.2025.1666311

1,202 views

Original Research

Published on 22 Sep 2025

Development of a refined neonatal rabbit model of necrotizing enterocolitis with relatively longer survival

in Gastrointestinal Sciences

Qing-Qing Guo
Hao Lin
Zhi-Xin Wang
Jian-Bo Wen
Juan-Juan Yang
Shi-Yun Lu

Frontiers in Physiology

doi 10.3389/fphys.2025.1643482

3,058 views

Original Research

Published on 25 Aug 2025

Crohn’s disease in coastal China: epidemiological profile and determinants of diagnostic delay in the Yancheng cohort

in Gastrointestinal Sciences

Shengnan Jin
Maozhen Zhang
Zixuan Zhou
Yanping Hao
Lin Wang
Su Xu

Frontiers in Physiology

doi 10.3389/fphys.2025.1643597

3,213 views

Review

Published on 10 Jul 2025

Navigating chronic pancreatitis pain: a pathophysiological and therapeutic overview

in Gastrointestinal Sciences

Zijin Lin
Stephen Pandol
Minoti Apte
Yi Jiang

Frontiers in Physiology

doi 10.3389/fphys.2025.1622845

6,864 views
2 citations

Editorial

Published on 30 Jun 2025

Editorial: Gastrointestinal damage and metabolic disorders

in Gastrointestinal Sciences

Carolina Silva Schiebel
Samilla Santos Souza Mazeti
Marcelo Biondaro Gois
Daniele Maria-Ferreira

Frontiers in Physiology

doi 10.3389/fphys.2025.1648739

2,485 views
2 citations

Original Research

Published on 03 Jun 2025

Modulation of gut microbiota and immune response by soy peptides mitigates irinotecan induced intestinal toxicity

in Gastrointestinal Sciences

Yongfa Jing
Dongli Yan

Frontiers in Physiology

doi 10.3389/fphys.2025.1538733

2,905 views
1 citation

Original Research

Published on 26 May 2025

Identification of autophagy-related genes in intestinal ischemia-reperfusion injury and their role in immune infiltration

in Gastrointestinal Sciences

Yichen Hu
Qinghua Zou
Yanbo Sun
Weiming Li
Zhaochuan Yin
Yuanpei Zhao
Kaiwen Shi
Hongyuan Liu
Jiahui Wang

Frontiers in Physiology

doi 10.3389/fphys.2025.1601968

3,351 views

Systematic Review

Published on 22 May 2025

The effects of heart rate variability biofeedback on functional gastrointestinal disorders: a scoping review

in Gastrointestinal Sciences

Ashley G. Pereira
Lily Fu
William Xu
Armen A. Gharibans
Greg O’Grady

Frontiers in Physiology

doi 10.3389/fphys.2025.1511391

3,345 views
3 citations

Original Research

Published on 24 Apr 2025

Association between non-high-density lipoprotein to high-density lipoprotein cholesterol ratio and bowel health in U.S. adults: a cross-sectional study

in Gastrointestinal Sciences

Wei Liu
Qirui Liu
Cheng Jiao
Jun Guo
Lipu Zhang
Yao Zhang
Guangchao Liu

Frontiers in Physiology

doi 10.3389/fphys.2025.1501171

3,482 views

572 articles

articles

Proinflammatory cytokines modify Ca2+ signaling and induce an apoptotic lipidome in murine small intestinal organoids

Endoscopic Excision for Internal and Mixed Hemorrhoids: A Retrospective Case Series of Short-Term Outcomes

The role of bile acid-activated receptor TGR5 in inflammation and liver diseases

Correction: Hypoxia promotes gastric cancer malignancy partly through the HIF-1α dependent transcriptional activation of the long non-coding RNA GAPLINC

Effect of enteral nutrition support combined with prone position mechanical ventilation on respiratory function, nutritional status, and inflammatory response in patients with severe pneumonia

Clinical application of capsule endoscopy in children with small bowel disease in Wuhan, China

Prolactin and oxytocin as modulators of intestinal contractility and glucose uptake

Effects of GLP-1 and GIP on cholinergic-induced contractility in isolated jejunal muscle from obese patients with and without type 2 diabetes mellitus

Potassium-competitive acid blockers and advances in the management of patients with acid-related diseases: a narrative review

Association between body mass index at different levels and risk of gastroesophageal reflux disease: a systematic review with dose-response meta-analysis

Efficacy of multimodal rehabilitation strategies on gastrointestinal function recovery in postoperative aortic dissection patients: a narrative review

The gut microbiome and gastrointestinal cancers: mechanisms, biomarkers and therapeutic opportunities

Physical capacity modulates intestinal barrier dysfunction in functional disorders: phenotype-specific patterns in fibromyalgia and irritable bowel syndrome

Machine learning-based algorithms for the prediction of 90-day survival in patients with liver failure receiving artificial liver therapy

Identifying key features for determining the patterns of patients with functional dyspepsia using machine learning

Development of a convolutional neural network-based AI-assisted multi-task colonoscopy withdrawal quality control system (with video)

Development of a refined neonatal rabbit model of necrotizing enterocolitis with relatively longer survival

Crohn’s disease in coastal China: epidemiological profile and determinants of diagnostic delay in the Yancheng cohort

Navigating chronic pancreatitis pain: a pathophysiological and therapeutic overview

Editorial: Gastrointestinal damage and metabolic disorders

Modulation of gut microbiota and immune response by soy peptides mitigates irinotecan induced intestinal toxicity

Identification of autophagy-related genes in intestinal ischemia-reperfusion injury and their role in immune infiltration

The effects of heart rate variability biofeedback on functional gastrointestinal disorders: a scoping review

Association between non-high-density lipoprotein to high-density lipoprotein cholesterol ratio and bowel health in U.S. adults: a cross-sectional study