ORIGINAL RESEARCH article
Front. Psychiatry
Sec. Addictive Disorders
Volume 16 - 2025 | doi: 10.3389/fpsyt.2025.1531905
This article is part of the Research TopicNeurobiology of substance use disorder, stress-related disorders, and their comorbidityView all 7 articles
Abnormal intrahemispheric and interhemispheric dynamic functional connectivity density in male alcohol use disorder
Provisionally accepted
Bohui Mei
Yarui Wei
Longyao Ma
Qiuying Tao
Jinghan Dang
JiePing Sun
Mengzhe Zhang
Yong Zhang*
Jingliang Cheng*- First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
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Background: Previous studies have demonstrated abnormal static intrahemispheric and interhemispheric functional connectivity between different brain regions in patients with alcohol use disorder (AUD). However, brain activity is highly dynamic.Methods: To address this, we analyzed the dynamic changes in intrahemispheric and interhemispheric connectivity patterns from 55 AUD patients and 32 healthy controls.The whole-brain functional connectivity was decomposed into ipsilateral and contralateral components, and the voxel-wise intrahemispheric and interhemispheric dynamic functional connectivity density (dFCD) was calculated using a sliding window analysis. At the same time, the relationship between dFCD values in abnormal brain riegions and clinical variables was conducted. Results: Our findings revealed that, compared to the HCs, AUD patients exhibited abnormal global, interhemispheric and intrahemispheric dFCD in the caudate, insula, parietal lobe, and occipital lobe. Furthermore, the dFCD values of these abnormal brain regions correlated with the average alcohol consumption and the severity of alcohol addiction in the AUD group. Conclusions: The results indicate that brain regions associated with the salience network, default mode network, and visual network exhibited intrahemispheric and interhemispheric abnormal functional connectivity. This study underscores that dynamic metrics can provide overlapping or complementary information alongside static metrics, contributing to a more comprehensive understanding of neural activity in AUD.
Keywords: alcohol use disorder, Dynamic functional connectivity density, intrahemisphere connections, interhemisphere connections, resting-state functional magnetic resonance imaging
Received: 21 Nov 2024; Accepted: 11 Jun 2025.
Copyright: © 2025 Mei, Wei, Ma, Tao, Dang, Sun, Zhang, Zhang and Cheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yong Zhang, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Jingliang Cheng, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
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