CLINICAL TRIAL article
Front. Psychiatry
Sec. Perinatal Psychiatry
Volume 16 - 2025 | doi: 10.3389/fpsyt.2025.1572633
This article is part of the Research TopicPerinatal mental health: Depression, Anxiety, Stress, and FearView all 10 articles
Effect of mindfulness group therapy on maternal psychological distress and perinatal outcomes in twin pregnancy: A randomized controlled trial
Provisionally accepted- 1Department of Obstetrics, First Affiliated Hospital of Chongqing Medical University, Chongqing, China
- 2School of Marxism, Chongqing University, Chongqing, China
- 3Department of Gastrointestinal Surgery, First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Purpose: Psychosocial stress, depression, and anxiety are prevalent during pregnancy and can be associated with adverse birth outcomes. This study aimed to evaluate the effectiveness of an online Mindfulness Group Therapy (MGT) program in improving perinatal maternal psychological distress and perinatal outcomes among women with twin pregnancies.In this randomized controlled trial, 120 women carrying twins were assigned to MGT groups (6-week, 120 minutes of mindfulness intervention weekly) or control groups (usual perinatal care and health education). The primary outcomes were maternal psychological distress, including depression, anxiety, stress, and mindfulness measured by the Edinburgh Postnatal Depression Scale, State Anxiety Inventory, Perceived Stress Scale, and Five Facet Mindfulness Questionnaire at three points: baseline, post-intervention and time one month postpartum. Secondary outcomes included maternal pregnancy outcomes and neonatal outcomes.Results: A total of 109 women with twin pregnancies completed the intervention. The intervention significantly and effectively prevented the worsening of postpartum depression symptoms in women with twin pregnancies, improved mindfulness, and reduced perceived stress (P < 0.05). Significant differences were observed at both post-intervention, and 1-month post-delivery (P < 0.05). However, no significant differences were found in anxiety scores (P > 0.05). Intention-to-treat analysis further revealed that the intervention had a significant effect on reducing postpartum depressive symptoms (P < 0.05), even when considering participants who did not complete the entire study process. In terms of pregnancy outcomes, a significant difference was found between the intervention and control groups in the incidence of low birth weight (P<0.05).MGT proves potentially effective in reducing perinatal stress, preventing prenatal depression, and decreasing the incidence of low-birth-weight infants in twin pregnancies. These findings support the integration of group mindfulness interventions into prenatal mental health care to mitigate prenatal depression among women expecting twins.
Keywords: twin pregnancies, Anxiety, Depression, mindfulness, Perinatal outcomes
Received: 07 Feb 2025; Accepted: 28 Apr 2025.
Copyright: © 2025 Zhou, Tang, Mei, Yang, Zheng, Liao and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Bi-Zhen Liao, Department of Obstetrics, First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Xin-Yang Yu, Department of Obstetrics, First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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