ORIGINAL RESEARCH article
Front. Psychiatry
Sec. Anxiety and Stress Disorders
This article is part of the Research TopicBidirectional Links Between Psychological Trauma and Physical Symptoms: Pathophysiology, Diagnosis, Prevention, and TreatmentView all 11 articles
Construction and validation of Nomogram prediction model for anxiety and depression in chemotherapy patients with multiple myeloma
Provisionally accepted
- 1Ganzhou People's Hospital, Ganzhou, Jiangxi Province, China
- 2The Second Affiliated Hospital, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
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Objective: To construct and validate a nomogram prediction model for anxiety and depression in chemotherapy patients with multiple myeloma (MM). Methods: From May 2021 to May 2023, 333 MM chemotherapy patients treaed at our hospital were selected. The patients were randomly divided into a modeling group and a validation group in a 7:3 ratio (using a random number table method). According to whether the modeling group patients had anxiety and depression, they were grouped into a non anxiety and depression group and an anxiety and depression group; a nomogram model constructed using R software was built to evaluate the predictive performance of the model. Clinical decision curves (DCA) were used to assess the value of the clinical application of the model. Results: Out of the 233 patients in this study, 66 experienced anxiety and depression, with an incidence rate of 28.33%. There were great differences in gender, economic income, education level, tumor staging, complications, and treatment plans between the anxiety and depression group and the non anxiety and depression group (P<0.05). The results of multivariate Logistic regression analysis showed that gender, education level, tumor stage, complications, and treatment plan were risk factors for anxiety and depression in MM chemotherapy patients (P<0.05), while economic income served as a protective factor (P<0.05). The AUC of the modelling group was 0.945, and the H-L test was χ2=8.579, P=0.674, with good agreement. The AUC of the validation group was 0.967, and the H-L test was χ2=7.315, P=0.698, with good consistency.The DCA curve shows that the probability of assessing anxiety and depression in patients undergoing MM chemotherapy is higher for clinical use when the probability is between 0.05 and 0.95. Conclusion: Gender, education, tumour stage, comorbidities and treatment regimen were risk factors for anxiety and depression in MM chemotherapy patients, while financial income was a protective factor for anxiety and depression in MM chemotherapy patients, and the constructed nomogram visually predicted the risk of anxiety and depression in MM chemotherapy patients.
Keywords: Multiple Myeloma, chemotherapy, Anxiety and depression, nomogram, Influence factor
Received: 17 Feb 2025; Accepted: 30 Nov 2025.
Copyright: © 2025 Wu, Li and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hui Li
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