CASE REPORT article
Front. Psychiatry
Sec. Psychopharmacology
This article is part of the Research TopicCase Reports in Psychopharmacology, vol IVView all 3 articles
Reversible Aripiprazole-Related Tardive Dyskinesia in Saudi Arabia: A Case Series and Literature Review
Provisionally accepted
Sultan M. Alshahrani
Ahmed S. Alyahya*Lujain Mohammed AlthagafiJameelah Abdullah SaeediLina Mohammed R. Aljohani
Aqeel A. Almarhoon- King Abdullah bin Abdulaziz University Hospital, Riyadh, Saudi Arabia
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Tardive dyskinesia (TD) is a slow-onset, hyperkinetic movement disorder involving repetitive involuntary movements. It is classified as a medication-induced movement disorder that occurs in association with the use of dopamine-blocking agents––most commonly, antipsychotics. It is classically understood as an unremitting process, with a few cases of reversible conditions and uncertain remission rates. Aripiprazole possesses a distinct and unique mechanism that decreases its risk compared to other antipsychotics. In this case series, we discuss three cases involving Saudi women who developed aripiprazole-related TD; notably, all cases remitted upon aripiprazole discontinuation or dose reduction without utilizing other forms of treatment. The current literature remains limited in describing aripiprazole-related TD, lacking a clear understanding of the development of TD following aripiprazole administration, the determined remission rate, and definite management.
Keywords: aripiprazole, aripiprazole-related tardive dyskinesia, case series, reversible tardive dyskinesia, Saudi Arabia, Tardive dyskinesia
Received: 18 Nov 2025; Accepted: 19 Jan 2026.
Copyright: © 2026 Alshahrani, Alyahya, Althagafi, Saeedi, Aljohani and Almarhoon. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ahmed S. Alyahya
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