MINI REVIEW article
Front. Rehabil. Sci.
Sec. Interventions for Rehabilitation
This article is part of the Research TopicPost-Acute COVID RehabilitationView all 16 articles
Transcranial Stimulation as a possible therapeutic proposal in Long COVID
Provisionally accepted
Lidiane Palheta Miranda dos SantosJulliana Vieira LeãoKetelen Yasmim Braga de Moraes SilvaDanilo Lameira dos SantosChrisllane Nascimento BatistaJonna Almeida Barros
Alna Paranhos
Apio Ricardo Nazareth Dias*
Luiz Fábio Magno Falcão- Universidade do Estado do Pará, Belem, Brazil
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The COVID-19 pandemic triggered an unprecedented global health crisis, with significant repercussions on the mental and neurological health of millions of individuals. Long COVID, characterized by persistent and debilitating symptoms, including chronic fatigue, pain, cognitive impairment, and mood swings, represents a substantial therapeutic challenge. In this context, neuromodulation emerges as a promising therapeutic strategy, offering new perspectives for the management of refractory neurological symptoms. This article aims to critically review the current evidence on the use of neuromodulation in patients with long COVID.
Keywords: Long Covid, neurologicalrehabilitation, Neuromodulation, Therapeutic interventions, transcranial stimulation
Received: 12 Dec 2025; Accepted: 09 Feb 2026.
Copyright: © 2026 Santos, Leão, Silva, Santos, Batista, Barros, Paranhos, Dias and Falcão. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Apio Ricardo Nazareth Dias
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.