Frontiers in Science Lead Article
Published on 07 Oct 2025
Precision cardiovascular medicine: shifting the innovation paradigm
Frontiers in Science
doi 10.3389/fsci.2025.1474469
- 71,226 views
- 4 citations
Lead article
Expert insights
ARTICLE EVENT
Discussion with the article authors
Join Prof Masanori Aikawa (Brigham and Women's Hospital, USA) and colleagues for a complimentary virtual symposium on next steps for precision cardiovascular medicine.
Date & time: 17 November 2025 at 16:00 CET
Frontiers in Science Editorial
Published on 07 Oct 2025
Conventional and precision medicine: opposites or complementary ends?
Prof Valentin Fuster, Prof Filip K. Swirski, and Prof Girish Nadkarni (Mount Sinai Health System, USA)—The future of cardiovascular medicine lies in integrating population-based and precision interventions that reduce global disease burden.
Frontiers in Science Editorial
Published on 07 Oct 2025
From one-size-fits-all to precision cardiovascular medicine
Dr Siyeon Rhee and Prof Joseph C. Wu (Stanford University School of Medicine, USA)—Precision cardiovascular medicine requires leveraging patient variability as an opportunity, not an obstacle, while embedding equity in both data collection and clinical implementation.
Frontiers in Science Viewpoint
Published on 07 Oct 2025
Toward precision cardiovascular medicine: progressing basic and translational science
Prof Rainer Schulz (Justus-Liebig University Giessen, Germany)—Stronger basic and translational science—including improved disease models, identification of cellular therapeutic targets, and safer delivery methods—is vital for the success of precision cardiovascular medicine.
Frontiers in Science Viewpoint
Published on 07 Oct 2025
Toward precision antithrombotic management
Prof Hugo ten Cate (Maastricht University Medical Center, the Netherlands)—Deep patient risk profiling can enable precision medicine approaches that safely match next-generation antithrombotic treatments to the right patients.
POLICY OUTLOOK
Published on 14 Oct 2025
Precision cardiovascular medicine: a time for global health leadership
Prof Amam Mbakwem (World Heart Federation, Nigeria)—Cardiovascular health for all demands national action plans that integrate precision approaches based on globally representative research—enabled by leadership committed to equitable access and context-relevant implementation.
Key points
Heterogeneity in the complex pathobiology and presentation of cardiovascular diseases (CVDs)—the leading cause of death globally—limits the effectiveness of conventional “one-size-fits-all” therapies.
Integrative systems approaches, which involve unbiased omics analyses (especially proteomics and single-cell analyses), bioinformatics, and network science, now offer the potential for a precision medicine innovation paradigm to tackle CVDs.
Artificial intelligence is driving new opportunities in patient profiling and computational precision drug design and development.
Various RNA therapeutics in development offer promise for effective precision therapy and could help address conventional drug development obstacles, such as cost and time.
Interdisciplinary and intersectoral collaboration throughout the research and innovation pathway, underpinned by global health policy leadership, is necessary to implement a precision cardiovascular medicine paradigm.
For all readers
EXPLAINER
Published on 07 Oct 2025
How precision medicine can transform the way we treat cardiovascular disease
A summary of the lead article in a Q&A format, with infographics and a video.
Frontiers for Young Minds
Published on 07 Oct 2025
Personalizing Heart Disease Treatment to Save Lives
A version of the lead article written for—and peer reviewed by—kids aged 8-15 years.
News
PRESS RELEASE
Published on 07 Oct 2025
AI and omics unlock personalized drugs and RNA therapies for heart disease
AI, omics, and systems biology can now help scientists design targeted drugs for cardiovascular disease pathways once thought “untreatable.” (Photos: Prof Masanori Aikawa, Prof Joseph Loscalzo, and Dr Sarvesh Chelvanambi, Brigham and Women's Hospital and Harvard Medical School, USA).
NEWS STORY
Published on 07 Oct 2025
AI and omics drive new path for precision cardiovascular drugs
Researchers used data-driven tools to target “undruggable” disease mechanisms.
NEWS STORY
Published on 07 Oct 2025
Cutting-edge technologies could trigger personalized CVD drug revolution
Personalized medicine for cardiovascular disease (CVD) could receive a huge boost through the application of the latest biomedical technologies, researchers report, but global leadership and partnership across many branches of healthcare are needed.