Frontiers in Systems Biology

Original Research

Published on 15 Jan 2026

A synthetic biology toolkit for rationally designing genetic circuits in Acinetobacter baumannii

Sara Letrari
Lisa Faccincani
Stefano Intini
Ilgin Ertan
Tommaso Varaschin
Francesca Galiazzo
Marco Costanzo
Giorgia D’angelo
Valentina Del Giudice
Luca Guarnieri

Frontiers in Systems Biology

doi 10.3389/fsysb.2025.1668595

1,633 views

Original Research

Published on 09 Jan 2026

Metagenomics enables the first detection of Trypanosoma sp. in Streblidae (Diptera: Hippoboscoidea) parasitizing bats in São Paulo, Brazil

Roberta Marcatti
Lucas Augusto Moysés Franco
Esmenia Coelho Rocha
Marcello Schiavo Nardi
Juliana Laurito Summa
Eric Thal Brambilla Cordeiro da Silva
Adriana Ruckert da Rosa
Débora Cardoso de Oliveira
Gustavo Graciolli
Ester Cerdeira Sabino

Frontiers in Systems Biology

doi 10.3389/fsysb.2025.1721019

848 views

Original Research

Accepted on 23 Dec 2025

Avian caecal microbiome response and resilience to Newcastle disease is dictated by breed background

Aqsa Ameer
Farrukh Saleem
Ciara Keating
Farhan Afzal
Hamid Irshad
Khurshid Ahmad
Sadia Sattar
Umer Zeeshan Ijaz
Sundus Javed

Frontiers in Systems Biology

302 views

Original Research

Published on 17 Dec 2025

Neural networks and foundation models: two strategies for EEG-to-fMRI prediction

Maël Donoso

Frontiers in Systems Biology

doi 10.3389/fsysb.2025.1715692

2,111 views

Original Research

Published on 08 Dec 2025

BioMedKG: multimodal contrastive representation learning in augmented BioMedical knowledge graphs

Tien Dang
Viet Thanh Duy Nguyen
Minh Tuan Le
Truong-Son Hy

Frontiers in Systems Biology

doi 10.3389/fsysb.2025.1651930

1,459 views

Original Research

Published on 03 Dec 2025

Towards effective cystic fibrosis gene therapy by optimizing prime editing and pulmonary-targeted LNPs

Kaya Sophie Lange
Lisa Marie Wiesner
Kathleen Susat
Vera Köhler
Malte Lenger
Christian Alexander Michalek
Anna-Lena Baack
Philip Frederic Mundt
Kai Kanthak
Isabell Alexandra Guckes

Frontiers in Systems Biology

doi 10.3389/fsysb.2025.1603749

2,376 views

Original Research

Published on 27 Oct 2025

The role of neutrophil-to-lymphocyte ratio in the prognosis of chronic kidney disease: insights from the NHANES cohort study

Ying Liu
Ru Wang
Jinguo Yuan
Jin Zhao

Frontiers in Systems Biology

doi 10.3389/fsysb.2025.1656683

1,321 views

Correction

Published on 27 Oct 2025

Correction: MicrobiomeKG: bridging microbiome research and host health through knowledge graphs

Frontiers Production Office

Frontiers in Systems Biology

doi 10.3389/fsysb.2025.1710604

869 views

Correction

Published on 23 Oct 2025

Correction: A guide to bayesian networks software for structure and parameter learning, with a focus on causal discovery tools

Francesco Canonaco
Joverlyn Gaudillo
Nicole Astrologo
Fabio Stella
Enzo Acerbi

Frontiers in Systems Biology

doi 10.3389/fsysb.2025.1717030

1,036 views

Hypothesis and Theory

Published on 21 Oct 2025

Structural properties and asymptotic behavior of bacterial two-component systems

Irene Zorzan
Chiara Cimolato
Luca Schenato
Massimo Bellato

Frontiers in Systems Biology

doi 10.3389/fsysb.2025.1693064

1,345 views

Original Research

Published on 17 Oct 2025

Dietary composition and fasting regimens differentially impact the gut microbiome and short-chain fatty acid profile in a Pakistani cohort

Farzana Gul
Hilde Herrema
Aqsa Ameer
Mark Davids
Arshan Nasir
Konstantinos Gerasimidis
Umer Zeeshan Ijaz
Sundus Javed

Frontiers in Systems Biology

doi 10.3389/fsysb.2025.1622753

3,067 views

Original Research

Published on 14 Oct 2025

Aging and activity patterns: actigraphy evidence from NHANES studies

Wen Luo
Matthew T. Scharf
Ioannis P. Androulakis

Frontiers in Systems Biology

doi 10.3389/fsysb.2025.1632110

2,013 views

Original Research

Published on 29 Sep 2025

GETgene-AI: a framework for prioritizing actionable cancer drug targets

Adrian Gu
Jake Y. Chen

Frontiers in Systems Biology

doi 10.3389/fsysb.2025.1649758

3,366 views

Original Research

Published on 15 Sep 2025

Digital patient modeling identifies predictive biomarkers of regorafenib response in elderly metastatic colorectal cancer

Juan Manuel García-Illarramendi
Pedro Matos-Filipe
Jose Manuel Mas
Judith Farrés
Xavier Daura

Frontiers in Systems Biology

doi 10.3389/fsysb.2025.1648559

2,069 views

Review

Published on 12 Sep 2025

Bridging academia and industry: advancing systems biology and QSP education through AstraZeneca’s collaborative partnerships

Cesar Pichardo-Almarza
Holly Kimko

Frontiers in Systems Biology

doi 10.3389/fsysb.2025.1627214

2,200 views

Brief Research Report

Published on 29 Aug 2025

MicrobiomeKG: bridging microbiome research and host health through knowledge graphs

Skye L. Goetz
Amy K. Glen
Gwênlyn Glusman

Frontiers in Systems Biology

doi 10.3389/fsysb.2025.1544432

3,412 views
2 citations

Mini Review

Published on 25 Aug 2025

A guide to bayesian networks software for structure and parameter learning, with a focus on causal discovery tools

Francesco Canonaco
Joverlyn Gaudillo
Nicole Astrologo
Fabio Stella
Enzo Acerbi

Frontiers in Systems Biology

doi 10.3389/fsysb.2025.1631901

4,153 views
2 citations

Methods

Published on 22 Aug 2025

From flux analysis to self contained cellular models

Andreas Kremling

Frontiers in Systems Biology

doi 10.3389/fsysb.2025.1546072

1,833 views
2 citations

Original Research

Published on 14 Aug 2025

A model-based design strategy to engineer miRNA-regulated detection systems

Renske J. Verkuijlen
Robert W. Smith

Frontiers in Systems Biology

doi 10.3389/fsysb.2025.1601854

1,824 views

Review

Published on 08 Aug 2025

Unraveling the role of mobile genetic elements in antibiotic resistance transmission and defense strategies in bacteria

Ranjith Kumavath
Puja Gupta
Eswar Rao Tatta
Mahima S. Mohan
Simi Asma Salim
Siddhardha Busi

Frontiers in Systems Biology

doi 10.3389/fsysb.2025.1557413

6,311 views
8 citations

Original Research

Published on 30 Jul 2025

A Pseudomonas fluorescens AND-gate biosensor for protein expression at plant root proximity

Nico van Donk
Antoine Raynal
Enrique Asin-Garcia

Frontiers in Systems Biology

doi 10.3389/fsysb.2025.1620608

2,825 views

Methods

Published on 03 Jul 2025

Learning Gaussian graphical models from correlated data

Zeyuan Song
Sophia Gunn
Stefano Monti
Gina M. Peloso
Ching-Ti Liu
Kathryn Lunetta
Paola Sebastiani

Frontiers in Systems Biology

doi 10.3389/fsysb.2025.1589079

1,984 views

Original Research

Published on 01 Jul 2025

Inflammation mediated brain damage and cytokine expression in a maternally derived murine model for preterm hypoxic-ischemic encephalopathy

Tyler C. Hillman
Braeden Jacobson
Kiara Piaggio Hurtado De Medoza
Marlene Lopez
Nicholas Iwakoshi
Christopher G. Wilson

Frontiers in Systems Biology

doi 10.3389/fsysb.2025.1517712

3,041 views

171 Publications

volumes

Volume 6 - 2026

Mathematical Modeling of Bone Remodeling after Surgical Menopause

Volume 5 - 2025

A synthetic biology toolkit for rationally designing genetic circuits in Acinetobacter baumannii

Metagenomics enables the first detection of Trypanosoma sp. in Streblidae (Diptera: Hippoboscoidea) parasitizing bats in São Paulo, Brazil

Avian caecal microbiome response and resilience to Newcastle disease is dictated by breed background

Neural networks and foundation models: two strategies for EEG-to-fMRI prediction

BioMedKG: multimodal contrastive representation learning in augmented BioMedical knowledge graphs

Towards effective cystic fibrosis gene therapy by optimizing prime editing and pulmonary-targeted LNPs

The role of neutrophil-to-lymphocyte ratio in the prognosis of chronic kidney disease: insights from the NHANES cohort study

Correction: MicrobiomeKG: bridging microbiome research and host health through knowledge graphs

Correction: A guide to bayesian networks software for structure and parameter learning, with a focus on causal discovery tools

Structural properties and asymptotic behavior of bacterial two-component systems

Dietary composition and fasting regimens differentially impact the gut microbiome and short-chain fatty acid profile in a Pakistani cohort

Aging and activity patterns: actigraphy evidence from NHANES studies

GETgene-AI: a framework for prioritizing actionable cancer drug targets

Digital patient modeling identifies predictive biomarkers of regorafenib response in elderly metastatic colorectal cancer

Bridging academia and industry: advancing systems biology and QSP education through AstraZeneca’s collaborative partnerships

MicrobiomeKG: bridging microbiome research and host health through knowledge graphs

A guide to bayesian networks software for structure and parameter learning, with a focus on causal discovery tools

From flux analysis to self contained cellular models

A model-based design strategy to engineer miRNA-regulated detection systems

Unraveling the role of mobile genetic elements in antibiotic resistance transmission and defense strategies in bacteria

A Pseudomonas fluorescens AND-gate biosensor for protein expression at plant root proximity

Learning Gaussian graphical models from correlated data

Inflammation mediated brain damage and cytokine expression in a maternally derived murine model for preterm hypoxic-ischemic encephalopathy