Research Topic

Quantitative Susceptibility Mapping in Neurodegeneration

About this Research Topic

Quantitative susceptibility mapping (QSM) is a novel contrast mechanics used in MRI. It is widely accepted that QSM has the outstanding advantages of converting phase shift to a localized magnetic susceptibility that is identified as the intrinsic property of the underlying tissues. Therefore, QSM has the ability to explore the pathogenesis of various neurodegenerative disease, such as, Parkinson’s disease (PD), Alzheimer’s disease (AD), Huntington's disease (HD), Multiple sclerosis (MS), etc.. For example, it has been well established that iron accumulation in the substantia nigra, especially in its inferior or posterior subregions, becomes a potentially core pathological characteristics for PD.

A growing number of evidence confirmed QSM role in quantifying tissue susceptibility such as tissue iron content and distribution, myelination, demyelination, and pathological susceptibility changes through which investigate the pathogenesis of neurodegeneration, and move forward to seek for imaging biomarkers that have the potential of clinical translations. Another very important role for QSM is measuring the venous oxygen saturation, and the resulting measurements could quantify the cerebrovascular information, provding valuable evidence for the influence of microvascular factors on the aging and neurodegenerations.

The aim of this Research Topic is to provide a better understanding of these neurodegenerative diseases in the novel views of tissue susceptibility alterations.

We welcome research articles and review articles focusing mainly, but not limited to the following issues:
• Investigations of tissue susceptibility alterations in PD, AD, HD and MS, and longitudinal studies with moderate to large sample sizes;
• The influence of venous oxygen saturation measured by QSM (microvascular factors) on the aging and neurodegenerations.
• Test-retest studies recruiting multi-center QSM data as valuable evidence for presenting QSM’s reproducibility and repeatability;
• Potential QSM’s clinical translations in neurodegeneration;
• QSM in vivo applications on animal models to clarify and validate clinical imaging findings associated with the core pathological hallmarks for specific neurodegenerations, e.g., the relationships between abnormal tissue susceptibility and α-synuclein, Tau and neuroinflammations;
• Suggestions and guidelines to improve QSM reconstructions and clinical protocols.


Keywords: Quantitative susceptibility mapping, neurodegeneration, tissue iron, myelination and demyelination


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Quantitative susceptibility mapping (QSM) is a novel contrast mechanics used in MRI. It is widely accepted that QSM has the outstanding advantages of converting phase shift to a localized magnetic susceptibility that is identified as the intrinsic property of the underlying tissues. Therefore, QSM has the ability to explore the pathogenesis of various neurodegenerative disease, such as, Parkinson’s disease (PD), Alzheimer’s disease (AD), Huntington's disease (HD), Multiple sclerosis (MS), etc.. For example, it has been well established that iron accumulation in the substantia nigra, especially in its inferior or posterior subregions, becomes a potentially core pathological characteristics for PD.

A growing number of evidence confirmed QSM role in quantifying tissue susceptibility such as tissue iron content and distribution, myelination, demyelination, and pathological susceptibility changes through which investigate the pathogenesis of neurodegeneration, and move forward to seek for imaging biomarkers that have the potential of clinical translations. Another very important role for QSM is measuring the venous oxygen saturation, and the resulting measurements could quantify the cerebrovascular information, provding valuable evidence for the influence of microvascular factors on the aging and neurodegenerations.

The aim of this Research Topic is to provide a better understanding of these neurodegenerative diseases in the novel views of tissue susceptibility alterations.

We welcome research articles and review articles focusing mainly, but not limited to the following issues:
• Investigations of tissue susceptibility alterations in PD, AD, HD and MS, and longitudinal studies with moderate to large sample sizes;
• The influence of venous oxygen saturation measured by QSM (microvascular factors) on the aging and neurodegenerations.
• Test-retest studies recruiting multi-center QSM data as valuable evidence for presenting QSM’s reproducibility and repeatability;
• Potential QSM’s clinical translations in neurodegeneration;
• QSM in vivo applications on animal models to clarify and validate clinical imaging findings associated with the core pathological hallmarks for specific neurodegenerations, e.g., the relationships between abnormal tissue susceptibility and α-synuclein, Tau and neuroinflammations;
• Suggestions and guidelines to improve QSM reconstructions and clinical protocols.


Keywords: Quantitative susceptibility mapping, neurodegeneration, tissue iron, myelination and demyelination


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

18 September 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

18 September 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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