Research Topic

Angiogenesis and Nutraceuticals

About this Research Topic

Angiogenesis is the formation of new blood vessels from the endothelial cells of pre-existing arteries, veins and capillaries. The process of angiogenesis is a hallmark of several physiological and pathological conditions. Angiogenesis contributes to tissue repair, expansion, and remodeling in physiological processes such as wound healing, ovulation and embryo development as well as to disease progression in various pathologies including cancer, atherosclerosis, cerebrovascular diseases and chronic inflammation. Many of these conditions share the same characteristics, for example the occurrence of hypoxia, inflammation or oxidative stress, recruitment of inflammatory cells, angiogenic growth factor production, basement membrane degradation, endothelial cell migration, proliferation and differentiation and modulation of vascular support cells.

Targeting the angiogenic process is at the present one of the main goals in pharmacology and there has been a great interest in the development of angiogenesis strategies that could inhibit tumor vascularization, diabetic retinopathy, inflammatory or cerebrovascular diseases. At present, the antiangiogenic therapy utilizes drugs that target either the angiogenic factors or angiogenic factor signal cascade. These drugs are known to pose several clinical limitations like the development of resistance and several side effects are associated with their administration which makes us focus on the importance of finding alternative strategies for controlling angiogenesis

In recent times, the diet-based approach is gaining more attention to target angiogenesis, which is evident from several reports showing the anti-angiogenesis effect of food components. A wide variety of bioactive compounds identified specifically in plants are known to possess anti-angiogenic effects by modulating different pathways. Thus, identification of natural food components for preventing or ameliorating angiogenesis associated complications would be of a greater advantage because of their low toxicity or limited side effects. The use of nutraceuticals with antioxidant and anti-inflammatory activities can also be a therapeutic option to maintain adequate vascularization, proper function of endothelial cells or to blunt aberrant angiogenesis.

In this Research Topic, we aim to present a collection of studies that joins Original Research articles, Methods, Mini Reviews, and Case Reports. Topics of particular interest include, but are not limited to:

• Angiogenic modulation by food components
• Antiangiogenic activity of nutraceuticals in cancer progression and angiogenic related diseases
• Synergistic activity of food components and antiangiogenic drugs
• Identification of angiogenic modulators present in food


For manuscripts dealing with plant extracts or other natural substances/compounds, the composition and the stability of the study material must be described in sufficient detail. In particular, for extracts, chromatograms with characterization of the dominating compound(s) are requested. The level of purity must be proven and included. Please refer to the Four Pillars of Best Practice in Ethnopharmacology, a subset of which concerning general standards in natural product research are applied to all such studies in all sections of Frontiers in Pharmacology.


Keywords: Angiogenesis, nutraceuticals, food components


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Angiogenesis is the formation of new blood vessels from the endothelial cells of pre-existing arteries, veins and capillaries. The process of angiogenesis is a hallmark of several physiological and pathological conditions. Angiogenesis contributes to tissue repair, expansion, and remodeling in physiological processes such as wound healing, ovulation and embryo development as well as to disease progression in various pathologies including cancer, atherosclerosis, cerebrovascular diseases and chronic inflammation. Many of these conditions share the same characteristics, for example the occurrence of hypoxia, inflammation or oxidative stress, recruitment of inflammatory cells, angiogenic growth factor production, basement membrane degradation, endothelial cell migration, proliferation and differentiation and modulation of vascular support cells.

Targeting the angiogenic process is at the present one of the main goals in pharmacology and there has been a great interest in the development of angiogenesis strategies that could inhibit tumor vascularization, diabetic retinopathy, inflammatory or cerebrovascular diseases. At present, the antiangiogenic therapy utilizes drugs that target either the angiogenic factors or angiogenic factor signal cascade. These drugs are known to pose several clinical limitations like the development of resistance and several side effects are associated with their administration which makes us focus on the importance of finding alternative strategies for controlling angiogenesis

In recent times, the diet-based approach is gaining more attention to target angiogenesis, which is evident from several reports showing the anti-angiogenesis effect of food components. A wide variety of bioactive compounds identified specifically in plants are known to possess anti-angiogenic effects by modulating different pathways. Thus, identification of natural food components for preventing or ameliorating angiogenesis associated complications would be of a greater advantage because of their low toxicity or limited side effects. The use of nutraceuticals with antioxidant and anti-inflammatory activities can also be a therapeutic option to maintain adequate vascularization, proper function of endothelial cells or to blunt aberrant angiogenesis.

In this Research Topic, we aim to present a collection of studies that joins Original Research articles, Methods, Mini Reviews, and Case Reports. Topics of particular interest include, but are not limited to:

• Angiogenic modulation by food components
• Antiangiogenic activity of nutraceuticals in cancer progression and angiogenic related diseases
• Synergistic activity of food components and antiangiogenic drugs
• Identification of angiogenic modulators present in food


For manuscripts dealing with plant extracts or other natural substances/compounds, the composition and the stability of the study material must be described in sufficient detail. In particular, for extracts, chromatograms with characterization of the dominating compound(s) are requested. The level of purity must be proven and included. Please refer to the Four Pillars of Best Practice in Ethnopharmacology, a subset of which concerning general standards in natural product research are applied to all such studies in all sections of Frontiers in Pharmacology.


Keywords: Angiogenesis, nutraceuticals, food components


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

12 August 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

12 August 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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