About this Research Topic
Infectious pathogens, in particular viruses including Epstein-Barr virus (EBV), hepatitis B and C viruses (HBV and HCV), human papilloma virus (HPV), among others, play a significant role in the development of human cancers, accounting for 20% of cancer cases worldwide, in which EBV, HBV and HCV, and HPV cause nasopharyngeal cancer, liver cancer, and cervical cancer, respectively. Not only can viral infection stimulate host immune responses to induce acute hyperinflammation and cause tissue damage, but it also influences tumor initiation and progression over a wide variety of ways, such as induction of genomic instability, metabolic reprogramming, chronic activation of inflammation, and alteration of tumor microenvironment.
In this Research Topic, we focus on understanding of the link between viral infection, tumor development and host immune response. The aim is to collect original research on cellular and molecular mechanism for viral infection-induced diseases with particular interest in host immune response and tumorigenesis as well as original studies related to biomedical applications including accurate diagnosis, precise prevention, and precise treatment.
We welcome the submission of original research papers, as well as reviews, research reports or specific comments on recently published articles including but not limited to:
• Preclinical research that furthers our understanding of the mechanisms underlying viruses stimulate or evade immune response, and microbe infection in tumorigenesis as well as molecular mechanisms of drug resistance.
• Translational research by focusing on identification of new drugs and new approaches for the development of diagnostic and therapeutic modalities for infectious diseases and cancer.
• Clinical studies informing diagnosis, treatment, and vaccine prevention for viral infection and the related cancer diseases.
Keywords: viral infection, inflammation, cancer, immune response, precise prevention and precise treatment
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.