Dietary macronutrient composition is a significant factor in determining human health. Specific dietary mediators of health and disease, including metabolically active carbohydrates and fats (e.g. fructose and trans-fats), have been identified and enable broad dietary recommendations at the population level. Genetic predispositions to metabolic disease include polymorphisms affecting preference for sweet or fatty foods. How the composition of dietary macronutrients in the context of an individual’s genome, microbiome, or medication list is less well studied, and deserves attention given the rise in metabolic syndrome, obesity, and type 2 diabetes along with the concomitant rise in consumption of processed and sugar-sweetened foods and beverages.
This research topic aims to explore the interplay between dietary macronutrient composition and human health, particularly in the context of metabolic health and disease. We hope to present and highlight the latest research and thinking uncovered by preclinical and clinical experiments, examining the interaction between genetics, microbiota, nutrient intake and preference, therapeutic interventions, and ultimately metabolic homeostasis and disease.
We welcome original research, systematic reviews, reviews, mini reviews, and perspectives as submissions to this research topic, which we hope will address the following themes:
How do dietary macronutrients influence metabolic health across tissues and organ systems?
How does dietary composition interact with underlying genetics to influence metabolic health?
How do dietary macronutrients impact therapeutic interventions to improve metabolic health?
Keywords: Metabolic disease; macronutrient composition; protein restriction, carbohydrate restriction; amino acid composition; lipid metabolism; energy metabolism; personalized medicine;
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
