Cholesterol Regulation in Health and Disease

Cholesterol is a critical organic molecule for maintaining cell survival, in particular membrane function. The core biosynthesis pathway, the mevalonate pathway, cross talks with a range of other critical paths responsible for maintaining human health. Dysregulated cholesterol biosynthesis is a known precursor for cardiovascular diseases, cancer and neurodegenerative disorders and recently disrupted cholesterol regulation has been identified as an indicator of sepsis via complex pathogenic and immune interactions.

The focus of this Research Topic is to highlight research at the forefront of insight into cholesterol regulation in a range of contexts. It will focus on experimental and theoretical approaches, both independently and together, used to investigate different aspects of cholesterol regulation. Theoretical approaches will include the use of bioinformatics, machine learning and mathematical modelling.

We are interested in work which seeks to understand cholesterol regulation from the molecular to the whole human scale. In this Research Topic, we welcome papers focusing on (but not limited to) elucidating specific aspects of the cholesterol biosynthesis pathway through to understanding cholesterol regulation in the context of related areas of health and disease. Work utilizing experimental and theoretical approaches (e.g. mathematical modeling) are encouraged as are manuscripts which combine both.