B-cell-mediated immunity has traditionally been associated with the adaptive immune system, primarily focusing on the production of high-affinity antibodies in response to specific antigens. However, recent research has identified specialized populations of unconventional B cells, known as innate B cells, which possess innate sensing capabilities and produce immunomodulatory cytokines and natural antibodies. These innate B cells, including B1 B cells and marginal zone B cells, have been identified in both humans and mice, exhibiting distinct phenotypes, localizations, and functional properties compared to conventional B cells. The study of innate B cells is an emerging field in B cell immunology, with the potential to redefine the role of B lymphocytes beyond their traditional adaptive immune functions. Despite these advancements, the regulation and physiological roles of innate B cell subsets in health and disease remain inadequately understood, highlighting the need for further investigation.
This research topic aims to illuminate the latest discoveries and advancements in the field of innate B cell research. By exploring the mechanisms underlying innate B cell function and their physiological significance, this topic seeks to enhance our understanding of these cells and inspire future research endeavors. The research will address current concepts and hypotheses regarding the roles of innate B cells in regulating normal immune function and their contributions to disease. The goal is to provide a comprehensive overview of the phenotypes, differentiation, functions, and therapeutic potential of innate B cells, thereby paving the way for new insights and applications in immunology.
To gather further insights into the differentiation, regulation, and physiological relevance of innate B cells, we welcome articles addressing, but not limited to, the following themes:
- Definition and classification of novel innate B cell subsets, their cellular origins, and nature contrasting the properties of conventional B cells.
- Networks of signal transduction pathways that drive the differentiation and activation of innate B cells.
- BCR repertoire analysis and the properties of antibodies produced by innate B cells.
- Crosstalk between innate B cells and other innate and adaptive immune cells.
- Physiological impacts of innate B cells in the context of infection, inflammatory disease, or other pathophysiological conditions.
Keywords: Innate B cell subsets, natural antibodies, BCR repertoire, signal transduction, infection, inflammatory disease
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
