About this Research Topic
Recent research has shown that cell behavior and pre-metastatic niche are active participants in the metastatic process and play a critical role in the success or failure of cancer cell colonization and therapy. This Research Topic aims to provide a forum to advance research on new mechanisms that would lead to novel strategies and cancer treatments that target cell behavior and pre-metastatic niches, leading to better clinical outcomes.
We welcome Brief Research Reports, Case Reports, Clinical Trials, Methods, Mini Reviews, Opinions, Original Research, Perspectives, Reviews, Study Protocols, and Systematic Reviews. Areas to be covered in this research topic may include, but are not limited to:
1. Metastasis and organ tropisms
2. Immune system and metastasis
3. In vitro and in vivo models to study metastasis
4. Regulation of the metastatic cascade
5. Pre-metastatic niche formation: role of primary tumor-derived extracellular vesicles
6. Organ colonization
7. Tumor cell dormancy
8. Treatment for Metastatic Cancer
Please note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in Frontiers in Oncology.
Keywords: Metastatic cascade, organ tropisms and colonization, primary tumor factors, extracellular vesicles, cancer cell dormancy, cancer treatment
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.