Infections caused by bacteria continue to be a significant global health challenge. In recent years advances in technology have led to significant progress in the understanding of host-pathogen interactions in bacterial infections. There is a growing interest in characterizing the metabolic response of both bacterial pathogens and the host during infection. Metabolomics is a powerful tool to explore the dynamic changes and metabolic network regulation of biological systems. Bacterial infection results in significant alterations in metabolic pathways in host cells. Metabolomics can identify abnormalities in metabolic pathways associated with bacterial infection by analyzing quantitative and qualitative changes in metabolites. By providing a comprehensive analysis of the metabolic interactions between host cells and bacteria, metabolomics provides a new perspective for an in-depth understanding of the mechanisms of bacterial infection. This approach is important in revealing the physiological adaptations of pathogenic bacteria, the regulation of virulence factors, changes in metabolic pathways, and the host response to infection.
This Research Topic aims to bring together studies on the application of metabolomics in bacterial infections to promote a comprehensive understanding of the mechanisms of infection and to provide insights into the development of new preventive and therapeutic strategies.
We welcome Original Research, Methods, Reviews, Mini-Reviews and Prospective articles focusing on, but not limited to, the following subtopics:
• Investigation of regulatory pathways by which bacterial infection affects host cell metabolism for survival and replication
• Understanding the impact of changes in host metabolism on bacteria
• Modulation of host autoimmune response by changes in host metabolism after infection
• Integrative metabolomics and other omics analysis for studying bacteria-host interaction
• Exploration of how bacterial virulence factors modulate host immune responses and disease progression through the modulation of host metabolic pathways
• Exploring the potential value of metabolic markers in the diagnosis and monitoring of bacterial infections to improve the early detection and diagnostic accuracy of infections
• Development of novel therapeutic strategies based on metabolomics
Keywords: bacterial infections, metabolomics, host-pathogen interactions, metabolic pathways, virulence factors
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
