Latest Advancements in Organ-on-a-Chip Technology

Organ-on-a-chip (OOAC) technology holds significant promise for pharmacology by providing a highly representative platform for drug testing and research. These miniature multicellular structures emulate human organ functions more accurately than traditional methods, enabling pharmacologists to estimate drug behavior in the human body with greater confidence. Importantly, OOACs also reduce reliance on animal testing and have the potential to expedite drug development by offering more efficient testing processes. Furthermore, OOACs facilitate the modeling of diseases, aiding in the understanding of their mechanisms and the development of targeted therapies. This technology is also an invaluable tool for advancing the concept of personalized medicine by using a patient's own cells, thereby tailoring treatments to individual genetic and physiological factors to improve drug efficacy and patient care.

This Research Topic will explore the cutting-edge developments and practical implications of this breakthrough technology. Broadly, we aim to highlight the latest advances in research in the area of OOACs and will consider manuscripts including but not limited to the following subtopics:

Precision Pharmacology with OOACs
OOACs and Drug Development Efficiency
Applications of multi-OOAC linking and multi-organ OOACs
Disease Modeling Using OOACs
Personalized Medicine and OOACs
Improving Drug Efficacy with OOAC Technology
Recent Innovations in OOAC Technology
Practical Implementation of OOACs in Pharmacology
Challenges and Future Directions in OOAC Research

We welcome a variety of article types, including under the following categories: Original Research, Review, Mini Review, Brief Research Report, and Perspective.

Topic Editor Ratnakar Potla is employed by Genentech, Inc. All other Topic Editors declare no competing interests with regards to the Research Topic subject.

Keywords: Organ-on-a-Chip, OOAC, Personalized Medicine, Targeted Therapy

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.