The rise of multidrug-resistant (MDR) bacteria presents a formidable challenge to public health, necessitating innovative strategies for diagnosis, treatment, and management. The intersection of nanotechnology and biophysics offers promising avenues for developing new antimicrobial therapies and diagnostic tools, leveraging the physicochemical properties of nanomaterials and the detailed understanding of microbial pathogenesis and host response mechanisms. Despite recent advances in nanomaterials and biophysical techniques for studying microbial infections, significant challenges remain in translating these findings into effective clinical applications. Current research has shown potential in using nanotechnology-based antimicrobials and biophysical methods to study pathogen-host interactions, yet there is a pressing need for more comprehensive studies that bridge the gap between laboratory research and clinical practice.
This research topic aims to address the escalating problem of antibiotic resistance through multidisciplinary approaches that combine nanotechnology, biophysics, and biomedical engineering. The main objectives include developing innovative methods to study and target MDR bacteria, fostering the creation of novel antimicrobial agents, diagnostic tools, and therapeutic strategies that can overcome resistance mechanisms and improve patient outcomes. Specific questions to be answered include how nanomaterials can be optimized for antimicrobial use, how biophysical techniques can elucidate pathogen-host interactions, and what engineering approaches can be employed to enhance diagnostic and therapeutic efficacy.
To gather further insights into the multidisciplinary approaches for combating MDR infections, we welcome articles addressing, but not limited to, the following themes:
- Development and application of nanotechnology-based antimicrobials and drug delivery systems.
- Biophysical methods for studying pathogen-host interactions and microbial pathogenesis.
- Engineering approaches to diagnose and treat ocular diseases, with a focus on glaucoma.
- Strategies to combat bacterial membrane resistance mechanisms.
- Interdisciplinary studies combining materials science, engineering, and biology to address MDR bacterial infections.
We encourage submissions of original research articles, reviews, and brief communications that provide new insights into the design, mechanism, and application of nanotechnology and biophysics in combating MDR bacteria. Studies on the development of novel antimicrobial materials, diagnostic approaches, and therapeutic strategies are particularly welcomed
Keywords: Nanotechnology, Biophysics, Multidrug-Resistant Bacteria, Antibiotic Resistance, Biomedical Engineering
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
