Cell Death in Kidney Diseases: Novel Biomarkers, Mechanisms, and Therapeutic Strategies

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ORIGINAL RESEARCH

Accepted on 27 May 2025

Luteolin delays the progression of IgA nephropathy by attenuating inflammation, oxidative stress and reducing extracellular matrix accumulation through activating the Nrf-2/HO-1 pathway

Dong-Yu Liang
Shao-Hua Cong
Lin-Hui Li
Qing-Qing Yi
Liping Tang
Li Ou Cao

doi 10.3389/fphar.2025.1530655

209 views

ORIGINAL RESEARCH

Accepted on 26 May 2025

Homotherapy for heteropathy of chronic kidney disease and oligoasthenozoospermia through regulating SIRT1/NF-κB pathway by Shenqi pills

Shuo Huang
Qihan Luo
Xinyue Li
Yiming Liu
Jiale Wei
Sichen Wang
Ping Qiu
Changyu Li

doi 10.3389/fphar.2025.1551423

120 views

ORIGINAL RESEARCH

Published on 30 Apr 2025

SuoquanYishen formula improves renal cellular senescence by inhibiting YTHDF1-Rubicon axis to promote autophagy in diabetic kidney disease

Zijie Yan
Lin Zhang
Tianpeng Ma
Yong Yuan
Yu Kang
Shuman Liu
BoCen Chen
Kai Li
Man Xiao
Yiqiang Xie

doi 10.3389/fphar.2025.1543277

923 views

ORIGINAL RESEARCH

Published on 29 Apr 2025

Synergistic amelioration of renal oxidative stress, inflammation, and fibrosis by combination of metformin and Clinacanthus nutans leave extracts in a type 2 diabetic rat model

Pongrapee Laorodphun
Saruda Thongyim
Sureeporn Suriyaprom
Pornchita Maphet
Yingmanee Tragoolpua
Thida Kaewkod
Aussara Panya
Phatchawan Arjinajarn

doi 10.3389/fphar.2025.1558341

738 views

ORIGINAL RESEARCH

Published on 28 Apr 2025

Integrating proteomics and network pharmacology to explore the relevant mechanism of Huangkui capsule in the treatment of chronic glomerulonephritis

Chang Qing Wen
Jia Zou
Jia Xuan Li
Fu Jiang Wang
Hai Tao Ge

doi 10.3389/fphar.2025.1560420

718 views

ORIGINAL RESEARCH

Published on 25 Apr 2025

HDAC3 inhibition mitigates acute kidney injury by alleviating RIPK1-mediated programmed necrosis

Manman Xie
Rui Hou
Runrun Shan
Xinyu Cheng
Pengcheng Wu
Xiufeng Luo
Yangyang Wei
Li Gao
Xiaoying Liu
Qi Chen

doi 10.3389/fphar.2025.1546950

735 views

REVIEW

Published on 24 Apr 2025

An update on renal tubular injury as related to glycolipid metabolism in diabetic kidney disease

Anqi Feng
Ruili Yin
Rong Xu
Baoyu Zhang
Longyan Yang

doi 10.3389/fphar.2025.1559026

869 views

ORIGINAL RESEARCH

Published on 16 Apr 2025

Multi - dimensional mechanism analysis of Choerospondias axillaris (Roxb.) Burtt et Hill in treating kidney stones: network pharmacology, molecular docking and in vitro experimental verification

Meiqi Qiu
Senhua Li
Yu Zhang
Jiaoxia Yan
Shiting Qin
Xijing Yin
Yujun Li
Chunhui Zeng
Ke Yang

doi 10.3389/fphar.2025.1501386

1,017 views

REVIEW

Published on 16 Apr 2025

Emerging roles of exosomes in the diagnosis and treatment of kidney diseases

Huanhuan Cao
Zixi Li
Jiajia Ye
Yi Lv
Chun Zhang
Tao Liang
Yumei Wang

doi 10.3389/fphar.2025.1525314

734 views

ORIGINAL RESEARCH

Published on 14 Apr 2025

5-methoxytryptophan ameliorates renal ischemia/reperfusion injury by alleviating endoplasmic reticulum stress-mediated apoptosis through the Nrf2/HO-1 pathway

Shaona Li
Hongjuan Yang
Bing Zhang
Lingyu Li
Xiangkun Li

doi 10.3389/fphar.2025.1506482

635 views

ORIGINAL RESEARCH

Published on 04 Apr 2025

Endoplasmic reticulum stress aggravates ferroptosis via PERK/ATF4/HSPA5 pathway in UUO-induced renal fibrosis

Zhigang Huang
Lihua Zhou
Bin Liu
Xiaoju Li
Yu Sang

doi 10.3389/fphar.2025.1545972

1,068 views

ORIGINAL RESEARCH

Published on 24 Mar 2025

Yiqi Qingre Gao alleviates renal fibrosis in UUO mice via PI3K/AKT pathway

Qi Jin
Qian Li
Liping Yang
Fang Ma
Huimin Mao
Yuyang Wang
Tongtong Liu
Liang Peng
Ping Li
Yongli Zhan

doi 10.3389/fphar.2025.1538061

756 views

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Renal Pharmacology

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Articles

Luteolin delays the progression of IgA nephropathy by attenuating inflammation, oxidative stress and reducing extracellular matrix accumulation through activating the Nrf-2/HO-1 pathway

Homotherapy for heteropathy of chronic kidney disease and oligoasthenozoospermia through regulating SIRT1/NF-κB pathway by Shenqi pills

SuoquanYishen formula improves renal cellular senescence by inhibiting YTHDF1-Rubicon axis to promote autophagy in diabetic kidney disease

Synergistic amelioration of renal oxidative stress, inflammation, and fibrosis by combination of metformin and Clinacanthus nutans leave extracts in a type 2 diabetic rat model

Integrating proteomics and network pharmacology to explore the relevant mechanism of Huangkui capsule in the treatment of chronic glomerulonephritis

HDAC3 inhibition mitigates acute kidney injury by alleviating RIPK1-mediated programmed necrosis

An update on renal tubular injury as related to glycolipid metabolism in diabetic kidney disease

Multi - dimensional mechanism analysis of Choerospondias axillaris (Roxb.) Burtt et Hill in treating kidney stones: network pharmacology, molecular docking and in vitro experimental verification

Emerging roles of exosomes in the diagnosis and treatment of kidney diseases

5-methoxytryptophan ameliorates renal ischemia/reperfusion injury by alleviating endoplasmic reticulum stress-mediated apoptosis through the Nrf2/HO-1 pathway

Endoplasmic reticulum stress aggravates ferroptosis via PERK/ATF4/HSPA5 pathway in UUO-induced renal fibrosis

Yiqi Qingre Gao alleviates renal fibrosis in UUO mice via PI3K/AKT pathway

Frontiers in Pharmacology

Renal Pharmacology