Unraveling the Mechanisms of Psychiatry Disorders

Psychiatric and mental disorders represent a significant challenge to global health, affecting millions worldwide. Schizophrenia impacts approximately 1 in 3000 individuals, while depression affects 5 out of 100 people, and around 2% of the population struggles with addiction. The COVID-19 pandemic has exacerbated these issues, with 1 in 8 people globally now living with a mental disorder. These statistics highlight the urgent need to address psychiatric disorders, which have profound implications for individual well-being and the global economy. Despite advances in understanding these disorders, significant gaps remain in comprehending the underlying molecular mechanisms. Recent studies have begun to explore the roles of inflammatory and oxidative stress processes, immune dysregulation, neuroplasticity modulation, and microbiome imbalances in the onset of psychiatric disorders. However, a comprehensive understanding of these mechanisms and their integration into therapeutic strategies is still lacking.

This Research Topic aims to unravel and integrate the molecular mechanisms associated with the onset of psychiatric disorders. By exploring these pathways, we aim to deepen our understanding of these molecular pathways and explore innovative treatments that could enhance the efficacy of existing therapies for disorders like schizophrenia, depression, bipolar disorders, autism, and addictions.

To gather further insights into the molecular mechanisms underlying psychiatric disorders, we welcome articles addressing, but not limited to, the following themes:

- The role of inflammatory and oxidative stress processes in psychiatric disorders.
- Immune dysregulation and its impact on mental health.
- Neuroplasticity modulation and its implications for treatment.
- The influence of microbiome imbalances on psychiatric conditions.
- Novel therapeutic interventions beyond traditional pharmacology.
- Preclinical and clinical studies exploring these mechanisms.
- Meta-analyses or reviews compiling robust evidence on these topics.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Conceptual Analysis
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Conceptual Analysis
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Registered Report
• Review
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: Molecular mechanisms, Schizophrenia, Depression, Addictions, Psychiatry, Microbiome, Inflammation, Oxidative Stress

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.