Exploring Small Molecule Probes: Advancements and Applications in Pharmacological Research

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ORIGINAL RESEARCH

Published on 16 Apr 2025

The development of a high-throughput acoustic droplet ejection mass-spectrometry assay and a solid-supported membrane (SSM)-based electrophysiological assay to study the pharmacological inhibition of SLC1-A3, -A2 and -A1 in a drug discovery program

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Antje Pommereau
Jennifer Warkentin
Thomas Licher
Felix Bärenz

doi 10.3389/fphar.2025.1544682

908 views

ORIGINAL RESEARCH

Published on 03 Feb 2025

Discovery of novel and highly potent small molecule inhibitors targeting FLT3-ITD for the treatment of acute myeloid leukemia using structure-based virtual screening and biological evaluation

Kun Shi
Ye Hong
Huajing Liu
Xiaotian Yang
Fengzhen Wang
Yanming Zhang

doi 10.3389/fphar.2025.1511257

786 views
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ORIGINAL RESEARCH

Published on 29 Nov 2024

Discovery of novel PARP1/NRP1 dual-targeting inhibitors with strong antitumor potency

Juanjuan Liu
Yifei Geng
Su Jiang
Lixia Guan
Junyi Gao
Miao-Miao Niu
Jindong Li

doi 10.3389/fphar.2024.1454957

878 views

ORIGINAL RESEARCH

Published on 30 Aug 2024

Radiosynthesis and in-vitro identification of a molecular probe 131I-FAPI targeting cancer-associated fibroblasts

Yaxin Tian
Yanghongyan Jiang
Ping Ma
Xiaowei Ma
Liang Du
Fengkui Wang
Xiaodong Yu

doi 10.3389/fonc.2024.1442601

1,102 views

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Frontiers in Pharmacology

Frontiers in Pharmacology

Experimental Pharmacology and Drug Discovery

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