Decoding the Epigenetic Landscape: Elucidating Cancer Pathology and Identifying Novel Therapeutic Targets

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ORIGINAL RESEARCH

Published on 04 Aug 2025

Revealing key regulatory factors in lung adenocarcinoma: the role of epigenetic regulation of autophagy-related genes from transcriptomics, scRNA-seq, and machine learning

Xianchang Zeng
Lingyun Wei
Lu Lv
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Xinliang Lu
Xianghui Kong
Zhijian Cai
Jianli Wang

doi 10.3389/fphar.2025.1542338

1,314 views

ORIGINAL RESEARCH

Published on 11 Apr 2025

Integrating multi-omics and experimental techniques to decode ubiquitinated protein modifications in hepatocellular carcinoma

Haikun Yang
Yuan Chen
Zheng Zhou
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Peng Li
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doi 10.3389/fphar.2025.1545472

1,847 views

ORIGINAL RESEARCH

Published on 19 Mar 2025

The real-world analysis of adverse events with azacitidine: a pharmacovigilance study based on the FAERS and WHO-VigiAccess databases

Zhaorui Wang
Linlin Guo
Youfu He
Baiquan Zhang
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Juan Ding

doi 10.3389/fphar.2025.1555838

3,063 views

ORIGINAL RESEARCH

Published on 18 Mar 2025

Characteristic analysis of adverse reactions of histone deacetylase inhibitors based on WHO-VigiAccess

Tongnan Yin
Yuyu Liu
Chenwen Li
Xinran Feng
Yumeng Lin
Zhongyu Qu

doi 10.3389/fphar.2025.1563797

1,213 views
1 citation

ORIGINAL RESEARCH

Published on 19 Feb 2025

Integration of multi-omics profiling reveals an epigenetic-based molecular classification of lung adenocarcinoma: implications for drug sensitivity and immunotherapy response prediction

Ning Wang
Yinan Li
Yaoyao Wang
Wenting Wang

doi 10.3389/fphar.2025.1540477

1,551 views
2 citations

ORIGINAL RESEARCH

Published on 18 Feb 2025

Exploring the role of epigenetic regulation in cancer prognosis with epigenetic score

Ruiguang Zhang
Shimin Jin
Qi Xu
Rongxiao Dai

doi 10.3389/fphar.2025.1538205

1,086 views

ORIGINAL RESEARCH

Published on 14 Feb 2025

Identification of potential diagnostic targets and therapeutic strategies for anoikis-related biomarkers in lung squamous cell carcinoma using machine learning and computational virtual screening

Xin Zhang
Jing Zou
Jinghua Ning
Yanhong Zhao
Run Qu
Yuzhe Zhang

doi 10.3389/fphar.2025.1500968

1,544 views

ORIGINAL RESEARCH

Published on 29 Jan 2025

NCAPD3-mediated ferroptosis of 2,3,5,4’-Tetrahydroxystilbene-2-O-β-D-glucoside inhibits proliferation in T47D cells

Jianfen Shen
Shuo Zhang
Yan Song
Leiming Yang
Qi Huang
Pengyu Wang
Youzhi Zhang

doi 10.3389/fphar.2024.1531220

1,440 views
2 citations

ORIGINAL RESEARCH

Published on 22 Jan 2025

Development and pan-cancer validation of an epigenetics-based random survival forest model for prognosis prediction and drug response in OS

Chaoyi Yin
Kede Chi
Zhiqing Chen
Shabin Zhuang
Yongsheng Ye
Binshan Zhang
Cailiang Cai

doi 10.3389/fphar.2025.1529525

1,353 views
1 citation

ORIGINAL RESEARCH

Published on 15 Jan 2025

Intratumor microbiome-derived butyrate promotes chemo-resistance in colorectal cancer

Linsheng Xu
Bingde Hu
Jingli He
Xin Fu
Na Liu

doi 10.3389/fphar.2024.1510851

2,378 views
4 citations

ORIGINAL RESEARCH

Published on 14 Jan 2025

DNA methylation inhibitors adverse reaction characteristic analysis: an analysis based on the European spontaneous adverse event reporting system

Xia Zhang
Yuyu Liu
Qingwang Hou
Yongxin Guo
Youfu He

doi 10.3389/fphar.2024.1527903

987 views

ORIGINAL RESEARCH

Published on 13 Jan 2025

Integration of histone modification-based risk signature with drug sensitivity analysis reveals novel therapeutic strategies for lower-grade glioma

Jingyuan Wang
Shuai Yan

doi 10.3389/fphar.2024.1523779

1,510 views

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Frontiers in Pharmacology

Pharmacology of Anti-Cancer Drugs

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Frontiers in Oncology
- Pharmacology of Anti-Cancer Drugs
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- 6.9 citescore

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Articles

Revealing key regulatory factors in lung adenocarcinoma: the role of epigenetic regulation of autophagy-related genes from transcriptomics, scRNA-seq, and machine learning

Integrating multi-omics and experimental techniques to decode ubiquitinated protein modifications in hepatocellular carcinoma

The real-world analysis of adverse events with azacitidine: a pharmacovigilance study based on the FAERS and WHO-VigiAccess databases

Characteristic analysis of adverse reactions of histone deacetylase inhibitors based on WHO-VigiAccess

Integration of multi-omics profiling reveals an epigenetic-based molecular classification of lung adenocarcinoma: implications for drug sensitivity and immunotherapy response prediction

Exploring the role of epigenetic regulation in cancer prognosis with epigenetic score

Identification of potential diagnostic targets and therapeutic strategies for anoikis-related biomarkers in lung squamous cell carcinoma using machine learning and computational virtual screening

NCAPD3-mediated ferroptosis of 2,3,5,4’-Tetrahydroxystilbene-2-O-β-D-glucoside inhibits proliferation in T47D cells

Development and pan-cancer validation of an epigenetics-based random survival forest model for prognosis prediction and drug response in OS

Intratumor microbiome-derived butyrate promotes chemo-resistance in colorectal cancer

DNA methylation inhibitors adverse reaction characteristic analysis: an analysis based on the European spontaneous adverse event reporting system

Integration of histone modification-based risk signature with drug sensitivity analysis reveals novel therapeutic strategies for lower-grade glioma

Frontiers in Pharmacology

Pharmacology of Anti-Cancer Drugs

Participating Journals

Frontiers in Oncology

Pharmacology of Anti-Cancer Drugs