Interactions among Immune Cells in Leishmaniasis: Exploring Markers, Enzymes and Cytokines

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ORIGINAL RESEARCH

Published on 27 Nov 2025

Functional and phenotypic analysis of CD4 T cell dynamics in peripheral blood of human visceral leishmaniasis patients confers increased frequencies of CD25 expressing regulatory T cells that contribute to disease pathogenesis

Mohd Kamran
Smriti Ghosh
Pradyot Bhattacharya
Sneha Ghosh Chaudhury
Anirban Bhattacharyya
George Banik
Mohammad Asad
Sarfaraz Ahmad Ejazi
Major Madhukar
3 more
Nahid Ali

doi 10.3389/fimmu.2025.1676937

676 views

ORIGINAL RESEARCH

Published on 14 Oct 2025

Non-additive strong gene interactions cause striking differences in organ pathology and cytokine response in Leishmaniasis

Yahya Sohrabi
Tatyana Kobets
Valeriya Volkova
Eliška Javorková
Imtissal Krayem
Alena Zajícová
Helena Havelková
Milena Svobodová
Vladimír Holáň
1 more
Marie Lipoldová

doi 10.3389/fimmu.2025.1579257

1,504 views

ORIGINAL RESEARCH

Published on 02 Oct 2025

The effect of treatment with a non-ionic surfactant vesicular formulation of sodium stibogluconate on host immune responses and serum metabolites in a murine model of Leishmania donovani

Raphael Taiwo Aruleba
Bernard Ong’ondo Osero
Du Toit Loots
Laneke Luies
Zama Cele
Priscilla Abena Ankamaa Opare
Mari van Reenen
Frank Brombacher
Katharine C. Carter
Ramona Hurdayal

doi 10.3389/fimmu.2025.1499513

1,615 views

MINI REVIEW

Published on 07 Aug 2025

Targeting macrophage phenotypes to prevent diseases caused by Leishmania and Trypanosoma cruzi infections

Natália S. Vellozo
Thayane C. Matos-Silva
Marcela F. Lopes

doi 10.3389/fimmu.2025.1595954

1,991 views

ORIGINAL RESEARCH

Published on 04 Aug 2025

Mice mucosal leishmaniasis model shown high parasite load, increased cytotoxicity and impaired IL-10+ T cell response

Alisson Amaral Da-Rocha
Júlio Souza Dos-Santos
Igor Santos Bittencourt
Douglas B. De-Almeida
Naiara Carla dos Santos Manhães
Hozany Praxedes
João Victor Paiva Romano
Elias Barbosa da Silva-Junior
Antônio José da Silva-Gonçalves
5 more
Herbert Leonel de Matos Guedes

doi 10.3389/fimmu.2025.1621781

1,738 views

CASE REPORT

Published on 05 Jun 2025

Case Report: Disseminated leishmaniasis and rheumatoid arthritis: navigating a clinical conundrum

Endrit Shahini
Donatello Marziliano
Francesco Losito
Marianna Zappimbulso
Elisabetta Cavalcanti
Raffaele Armentano
Fabio Fucilli
Raffaele Cozzolongo
Giuseppe Ingravallo
5 more
Antonio Giovanni Solimando

doi 10.3389/fimmu.2025.1599381

2,759 views
1 citation

ORIGINAL RESEARCH

Published on 05 May 2025

Blue light-emitting diode phototherapy presents in vitro efficacy against distinct Leishmania species and is therapeutic against tegumentary leishmaniasis in BALB/c mice

Breno Luiz Pimenta
Daniela Pagliara Lage
Camila Simões de Freitas
Danniele Luciana Vale
Karolina Oliveira de Melo Falcão
Saulo Samuel Gonçalves Dias
Raquel Soares Bandeira Câmara
Isabela Amorim Gonçalves Pereira
Ana Luiza Silva
4 more
André Talvani

doi 10.3389/fimmu.2025.1554051

2,085 views
1 citation

ORIGINAL RESEARCH

Published on 21 Mar 2025

HIF-α signaling regulates the macrophage inflammatory response during Leishmania major infection

Lucy G. Fry
Charity L. Washam
Hayden Roys
Anne K. Bowlin
Gopinath Venugopal
Jordan T. Bird
Stephanie D. Byrum
Tiffany Weinkopff

doi 10.3389/fimmu.2025.1487311

2,252 views
1 citation

REVIEW

Published on 12 Mar 2025

Insights to the HIV-associated visceral leishmaniasis clinical outcome: lessons learned about immune mediated disorders

Maria Luciana Silva-Freitas
Gabriela Corrêa-Castro
Alda Maria Da-Cruz
Joanna Reis Santos-Oliveira

doi 10.3389/fimmu.2025.1516176

1,990 views

ORIGINAL RESEARCH

Published on 22 Oct 2024

Leishmania major surface components and DKK1 signalling via LRP6 promote migration and longevity of neutrophils in the infection site

Olivia C. Ihedioha
Haley Q. Marcarian
Anutr Sivakoses
Stephen M. Beverley
Diane McMahon-Pratt
Alfred L. M. Bothwell

doi 10.3389/fimmu.2024.1473133

2,437 views
2 citations

ORIGINAL RESEARCH

Published on 21 Oct 2024

Lesional senescent CD4+ T cells mediate bystander cytolysis and contribute to the skin pathology of human cutaneous leishmaniasis

Luciana Polaco Covre
Carlos Henrique Fantecelle
Renan Garcia de Moura
Paola Oliveira Lopes
Isabela Valim Sarmento
Celio Geraldo Freire-de-Lima
Debora Decote-Ricardo
Herbert Leonel de Matos Guedes
Alessandra Marcia da Fonsceca-Martins
5 more
Daniel Claudio Oliveira Gomes

doi 10.3389/fimmu.2024.1475146

2,623 views

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Articles

Functional and phenotypic analysis of CD4 T cell dynamics in peripheral blood of human visceral leishmaniasis patients confers increased frequencies of CD25 expressing regulatory T cells that contribute to disease pathogenesis

Non-additive strong gene interactions cause striking differences in organ pathology and cytokine response in Leishmaniasis

The effect of treatment with a non-ionic surfactant vesicular formulation of sodium stibogluconate on host immune responses and serum metabolites in a murine model of Leishmania donovani

Targeting macrophage phenotypes to prevent diseases caused by Leishmania and Trypanosoma cruzi infections

Mice mucosal leishmaniasis model shown high parasite load, increased cytotoxicity and impaired IL-10+ T cell response

Case Report: Disseminated leishmaniasis and rheumatoid arthritis: navigating a clinical conundrum

Blue light-emitting diode phototherapy presents in vitro efficacy against distinct Leishmania species and is therapeutic against tegumentary leishmaniasis in BALB/c mice

HIF-α signaling regulates the macrophage inflammatory response during Leishmania major infection

Insights to the HIV-associated visceral leishmaniasis clinical outcome: lessons learned about immune mediated disorders

Leishmania major surface components and DKK1 signalling via LRP6 promote migration and longevity of neutrophils in the infection site

Lesional senescent CD4+ T cells mediate bystander cytolysis and contribute to the skin pathology of human cutaneous leishmaniasis

Frontiers in Immunology

Parasite Immunology