Expanding Therapeutic Horizons with Non-Invasive Vagus Nerve Stimulation

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ORIGINAL RESEARCH

Published on 26 Aug 2025

Combined minimally invasive vagal cranial nerve and trigeminocervical complex peripheral nerve stimulation produces prolonged improvement of severe painful peripheral neuropathy and hyperglycemia in type 2 diabetes

Peter S. Staats
Alyssa Staats
Brittny Mikhaiel
Jason Chen
Eric Azabou
Claire-Marie Rangon

doi 10.3389/fnins.2025.1644961

4,561 views

CLINICAL TRIAL

Published on 11 Aug 2025

Feasibility of vagus nerve modulation (VNMM/taVNS) in cognitive-swallowing dual-task paradigms: a fNIRS pilot study

Zhiyong Wang
Keling Cheng
Junhui Bai
Cuicui Zhang
Jun Ni

doi 10.3389/fnins.2025.1619532

1,821 views

CASE REPORT

Published on 03 Jul 2025

Case Report: Effect of transcutaneous auricular vagus nerve stimulation on acute pain after external fixation for bilateral open tibiofibular fractures

Qi Li
Donglin Zhao
Shuyang Zhang
Xinyu Du
Ning Ding
Zheng Xing
Xiaolei Chu
Weiguo Xu

doi 10.3389/fnins.2025.1586632

2,348 views

HYPOTHESIS AND THEORY

Published on 02 Jun 2025

New intervention strategy for postoperative fatigue syndrome in elderly patients with colorectal cancer: a clinical hypothesis study based on vagus nerve stimulation

Xuefeng Yin
Shuang Qiao
Ling Zhang
Zhonghua Li
Qin Zhang
Yu Shen
Keyu Fan
Mingxia Liu
Dongxu Wang
6 more
He Liu

doi 10.3389/fmed.2025.1588850

2,358 views

STUDY PROTOCOL

Published on 30 May 2025

Effect of transcranial magnetic stimulation combined with transcutaneous auricular vagus nerve stimulation on mild cognitive impairment: a study protocol for a randomized controlled trial

Jingjing Zhang
Jun Ma
Yao Rao
Jiali Wu
Hui Xu
Jiawei Ni
Zhiwei Zhao
Cong Wang
Chunlei Shan

doi 10.3389/fnagi.2025.1600921

2,675 views

ORIGINAL RESEARCH

Published on 28 Apr 2025

Effects of off-line auricular transcutaneous vagus nerve stimulation (taVNS) on a short-term memory task: a pilot study

Francesco Fisicaro
Klizia Cortese
Rita Bella
Manuela Pennisi
Giuseppe Lanza
Kaoru Yuasa
Yoshikazu Ugawa
Yasuo Terao

doi 10.3389/fnagi.2025.1549167

3,702 views
1 citation

STUDY PROTOCOL

Published on 18 Mar 2025

Neuroregulatory and clinical efficacy of auricular vagus nerve stimulation in elderly patients with chronic insomnia comorbid with functional dyspepsia: protocol for a randomized controlled trial

Hao Zhou
Xing Tang
Dan Wang
Zubo Huang
Yue Zeng
Shanshan Liu
Chao Wang

doi 10.3389/fmed.2025.1537515

3,987 views
3 citations

ORIGINAL RESEARCH

Published on 29 Jan 2025

Low-level auricular vagus nerve stimulation lowers blood pressure and heart rate in paroxysmal atrial fibrillation patients: a self-controlled study

Yu Jiang
Di Su
Jingwen Xiao
Wenbo Cheng
Yuemei Hou
Yan Zhang

doi 10.3389/fnins.2025.1525027

2,289 views
2 citations

REVIEW

Published on 15 Jan 2025

Mechanisms of vagus nerve stimulation for the treatment of neurodevelopmental disorders: a focus on microglia and neuroinflammation

Makenna Gargus
Benneth Ben-Azu
Antonia Landwehr
Jaclyn Dunn
Joseph P. Errico
Marie-Ève Tremblay

doi 10.3389/fnins.2024.1527842

8,070 views
10 citations

REVIEW

Published on 13 Nov 2024

Non-invasive vagus nerve stimulation in anti-inflammatory therapy: mechanistic insights and future perspectives

Fu-Jun Liu
Jing Wu
Li-Jun Gong
Hong-Shuai Yang
Huan Chen

doi 10.3389/fnins.2024.1490300

13,610 views
12 citations

ORIGINAL RESEARCH

Published on 05 Nov 2024

Transcutaneous auricular vagal nerve stimulation modulates blood glucose in ZDF rats via intestinal melatonin receptors and melatonin secretion

Yuzhengheng Zhang
Ningyi Zou
Chen Xin
Yifei Wang
Zixuan Zhang
Peijing Rong
Shaoyuan Li

doi 10.3389/fnins.2024.1471387

2,687 views
4 citations

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Articles

Combined minimally invasive vagal cranial nerve and trigeminocervical complex peripheral nerve stimulation produces prolonged improvement of severe painful peripheral neuropathy and hyperglycemia in type 2 diabetes

Feasibility of vagus nerve modulation (VNMM/taVNS) in cognitive-swallowing dual-task paradigms: a fNIRS pilot study

Case Report: Effect of transcutaneous auricular vagus nerve stimulation on acute pain after external fixation for bilateral open tibiofibular fractures

New intervention strategy for postoperative fatigue syndrome in elderly patients with colorectal cancer: a clinical hypothesis study based on vagus nerve stimulation

Effect of transcranial magnetic stimulation combined with transcutaneous auricular vagus nerve stimulation on mild cognitive impairment: a study protocol for a randomized controlled trial

Effects of off-line auricular transcutaneous vagus nerve stimulation (taVNS) on a short-term memory task: a pilot study

Neuroregulatory and clinical efficacy of auricular vagus nerve stimulation in elderly patients with chronic insomnia comorbid with functional dyspepsia: protocol for a randomized controlled trial

Low-level auricular vagus nerve stimulation lowers blood pressure and heart rate in paroxysmal atrial fibrillation patients: a self-controlled study

Mechanisms of vagus nerve stimulation for the treatment of neurodevelopmental disorders: a focus on microglia and neuroinflammation

Non-invasive vagus nerve stimulation in anti-inflammatory therapy: mechanistic insights and future perspectives

Transcutaneous auricular vagal nerve stimulation modulates blood glucose in ZDF rats via intestinal melatonin receptors and melatonin secretion

Frontiers in Neuroscience

Autonomic Neuroscience

Translational Neuroscience

Other participating journals

Frontiers in Integrative Neuroscience

Frontiers in Physiology

Autonomic Neuroscience