Inflammatory mechanisms are key hallmarks in several high-impact diseases, including cancer, vascular diseases, and neurodegenerative conditions. Although much progress and efforts in scientific approaches have been reached so far, there is still more to be explored and understood. In-depth studies of biological cues related to inflammation across different pathological models are pivotal for understanding their use as key triggers for drug delivery and targeted treatments, including personalized.
The goal of this Research Topic is to provide an overview of the recent advances in the development of biochemical, mechanobiological, and biological signals to the cells within an inflamed tissue environment. Inflammatory mechanisms directly correlate with nowadays high-impact diseases, such as cancer, vascular issues/atherosclerosis, and neurodegenerative conditions. Therefore, bearing in mind the rising need for personalized medicine, it is of pivotal importance to merge the biological overview, in order to reach a specific targeted delivery to the affected tissue/organ/physiological area. Hence, starting from in-vitro, ex-vivo, and/or in-vivo info to the fabrication of innovative stimuli-triggered platform is expected to boost the scientific approaches and foster the availability of innovative options to patients.
All types of manuscripts regarding inflammatory conditions, their biological basis, their importance over high-impact diseases, and their use as triggers for nanomedicine/innovative drug delivery approaches are welcomed, including original research articles, reviews, mini-reviews, and opinions.
Areas to be covered in this Research Topic may include, but are not limited to, the following:
• Systems biological approaches on biomedicine • Biological bases for inflammation • Mechanobiology • Models of healthy and diseased tissue/organs (including cancer, atherosclerosis, neurodegenerative models) • Models of development/morphogenesis (including organoids or 3D models) • Cells-ECM interactions • Stimuli-responsive carriers • Natural and synthetic biomaterials • Biofabrication strategies • Dynamic scaffolds • Triggered drug/gene delivery approaches • Personalized medicine/nanomedicine
Article types and fees
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Brief Research Report
Case Report
Data Report
Editorial
FAIR² Data
FAIR² DATA Direct Submission
General Commentary
Hypothesis and Theory
Methods
Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.
Article types
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Brief Research Report
Case Report
Data Report
Editorial
FAIR² Data
FAIR² DATA Direct Submission
General Commentary
Hypothesis and Theory
Methods
Mini Review
Opinion
Original Research
Perspective
Review
Systematic Review
Technology and Code
Keywords: Inflammatory mechanisms, drug delivery, nanomedicine, stimuli-responsiveness, biological bases for inflammation, atherosclerosis, cancer -neurodegeneration, systems biological approaches on biomedicine
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
