The Role of Metabolic Reprogramming in Tumor Therapy

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ORIGINAL RESEARCH

Published on 02 Sep 2025

Integrative single-cell and machine learning analysis predicts lactylation-driven therapy resistance in prostate cancer: a molecular docking and experiments-validated framework for treatment optimization

Zhiyu Liu
Yuqi Li
Juan Wang
Yang Zeng
Qilong Wu
Xinyao Zhu
Tao Zhou
Qingfu Deng

doi 10.3389/fimmu.2025.1647384

612 views

REVIEW

Published on 06 Aug 2025

PKM2-driven metabolic reprogramming in digestive system tumors: mechanisms, therapeutic advances, and clinical challenges

Xinyao Huang
Jianjun He
Haonan Sun
Yi Wu
Renjun Gu
Ziyun Li

doi 10.3389/fimmu.2025.1634786

1,102 views

REVIEW

Published on 01 Aug 2025

Interplay between bile acids, gut microbiota, and the tumor immune microenvironment: mechanistic insights and therapeutic strategies

Yan Tong
Xiaojun Lou

doi 10.3389/fimmu.2025.1638352

1,537 views

REVIEW

Published on 14 Jul 2025

Research progress on the interaction between glucose metabolic reprogramming and lactylation in tumors

Yi Yang
Yi Wu
Hui Chen
Zehai Xu
Ruisi Lu
Sijie Zhang
Rui Zhan
Qinghua Xi
Yunfeng Jin

doi 10.3389/fimmu.2025.1595162

2,523 views

MINI REVIEW

Published on 09 Jul 2025

Immunosuppressive mechanisms and therapeutic targeting of regulatory T cells in ovarian cancer

Jing Li
Haojun Huang
Renxian Xie
Rongying Yang
Haitao Wang
Li Wan

doi 10.3389/fimmu.2025.1631226

1,701 views

ORIGINAL RESEARCH

Published on 04 Jul 2025

Integrative single-cell and spatial transcriptomics uncover ELK4-mediated mechanisms in NDUFAB1+ tumor cells driving gastric cancer progression, metabolic reprogramming, and immune evasion

Yuwei Sun
Wenyang Nie
Zhikai Xiahou
Xiaojing Wang
Wenjia Liu
Zongkai Liu
Zhiheng Lin
Zhaidong Liu

doi 10.3389/fimmu.2025.1591123

1,793 views
2 citations

ORIGINAL RESEARCH

Published on 26 Jun 2025

Integrated analysis of single-cell RNA-seq and spatial transcriptomics to identify the lactylation-related protein TUBB2A as a potential biomarker for glioblastoma in cancer cells by machine learning

Yifan Xu
Chonghui Zhang
Jinpeng Wu
Pin Guo
Nan Jiang
Chao Wang
Yugong Feng

doi 10.3389/fimmu.2025.1601533

2,532 views

SYSTEMATIC REVIEW

Published on 09 Jun 2025

LDH and glycolytic activity as predictors of immunotherapy response in gastric cancer: a systematic review and meta-analysis

Li Zhu
Juanjuan Ruan
Qing Zhang
Li Feng
Ying Deng
Lili Dai
Yuanyuan Zheng
Zhijuan Feng
Ruihan Xu
1 more
Nan Xu

doi 10.3389/fimmu.2025.1605976

2,170 views

ORIGINAL RESEARCH

Published on 06 Jun 2025

Unraveling the role of GPCR signaling in metabolic reprogramming and immune microenvironment of lung adenocarcinoma: a multi-omics study with experimental validation

Zhaoxuan Wang
Cheng Wang
Shilei Zhao
Chundong Gu

doi 10.3389/fimmu.2025.1606125

1,983 views

ORIGINAL RESEARCH

Published on 01 May 2025

Integrative single-cell RNA sequencing and bulk RNA sequencing reveals the characteristics of glutathione metabolism and protective role of GSTA4 gene in pancreatic cancer

Xinya Jia
Qiang Zhang
Zhe Wang
Jianliang Cao
Anran Song
Chao Lan
Yuepeng Hu

doi 10.3389/fimmu.2025.1571431

1,914 views
1 citation

MINI REVIEW

Published on 30 Apr 2025

Metabolic reprogramming in hepatocellular carcinoma: mechanisms of immune evasion and therapeutic implications

Bocheng Gao
Yan Lu
Xingyue Lai
Xi Xu
Shuhua Gou
Zhida Yang
Yanju Gong
Hong Yang

doi 10.3389/fimmu.2025.1592837

3,438 views
2 citations

MINI REVIEW

Published on 30 Apr 2025

Metabolic reprogramming and immune microenvironment characteristics in laryngeal carcinoma: advances in immunotherapy

Kexin Ma
Qingjie Mao
Bing Fei
Tingting Ni
Zhenxin Zhang
Haosheng Ni

doi 10.3389/fimmu.2025.1589243

1,785 views

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Frontiers in Immunology

Cancer Immunity and Immunotherapy

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Frontiers in Oncology
- Cancer Immunity and Immunotherapy
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Articles

Integrative single-cell and machine learning analysis predicts lactylation-driven therapy resistance in prostate cancer: a molecular docking and experiments-validated framework for treatment optimization

PKM2-driven metabolic reprogramming in digestive system tumors: mechanisms, therapeutic advances, and clinical challenges

Interplay between bile acids, gut microbiota, and the tumor immune microenvironment: mechanistic insights and therapeutic strategies

Research progress on the interaction between glucose metabolic reprogramming and lactylation in tumors

Immunosuppressive mechanisms and therapeutic targeting of regulatory T cells in ovarian cancer

Integrative single-cell and spatial transcriptomics uncover ELK4-mediated mechanisms in NDUFAB1+ tumor cells driving gastric cancer progression, metabolic reprogramming, and immune evasion

Integrated analysis of single-cell RNA-seq and spatial transcriptomics to identify the lactylation-related protein TUBB2A as a potential biomarker for glioblastoma in cancer cells by machine learning

LDH and glycolytic activity as predictors of immunotherapy response in gastric cancer: a systematic review and meta-analysis

Unraveling the role of GPCR signaling in metabolic reprogramming and immune microenvironment of lung adenocarcinoma: a multi-omics study with experimental validation

Integrative single-cell RNA sequencing and bulk RNA sequencing reveals the characteristics of glutathione metabolism and protective role of GSTA4 gene in pancreatic cancer

Metabolic reprogramming in hepatocellular carcinoma: mechanisms of immune evasion and therapeutic implications

Metabolic reprogramming and immune microenvironment characteristics in laryngeal carcinoma: advances in immunotherapy

Frontiers in Immunology

Cancer Immunity and Immunotherapy

Participating Journals

Frontiers in Oncology

Cancer Immunity and Immunotherapy