Nanozymes, a novel class of nanomaterials with enzyme-like activities, have emerged as a promising tool for treating various diseases by modulating reactive oxygen species (ROS). Nanozymes can mimic the function of natural antioxidant enzymes such as superoxide dismutase, catalase, and glutathione peroxidase, thereby protecting normal cells from oxidative damage and mitigating inflammation. Conversely, their pro-oxidant properties can be harnessed to target tumors and bacterial infections effectively. The design of nanozymes for in vivo applications necessitates a thorough understanding of their catalytic activity, as well as their structural and surface properties, to ensure optimal interactions within the disease microenvironment. This Research Topic aims to delve into recent advancements in nanozyme development and their therapeutic applications.
The goal of this Research Topic is to address the challenges and opportunities in the application of nanozymes for in vivo therapeutic purposes. While nanozymes have demonstrated significant potential in regulating reactive oxygen species and treating various diseases, there remain critical issues related to their design, stability, targeted delivery, and biocompatibility. Achieving precise control over their catalytic activity and minimizing potential adverse effects is essential for their successful clinical translation. This Research Topic seeks to explore innovative strategies to enhance the therapeutic efficacy of nanozymes, including advanced design principles, surface modifications, and targeted delivery systems. By bringing together recent advancements in nanozyme research, we aim to provide a comprehensive understanding of how to optimize nanozymes for effective and safe use in living organisms.
This Research Topic focuses on the in vivo applications of nanozymes, with an emphasis on their design, functionality, and therapeutic potential. We encourage contributions that explore themes include the following, but are not limited to: 1. Development of nanozymes for antioxidative and pro-oxidant therapeutic uses, 2. Biological mechanisms of nanozyme-driven biocatalytic reactions, 3. Nanozymes as vectors in targeted drug delivery systems, 4. Disease-specific utilizations, including cancer, inflammation, neurological disorders, and bacterial infection control, 5. Interaction between nanozymes with the disease microenvironment, 6. Enhancements in biocompatibility, 7. Strategies for optimizing targeted delivery systems.
We call for submissions of original research articles, reviews, and perspectives that provide insights into the latest advancements in nanozyme technology, existing challenges, and future directions in their clinical translation.
Article types and fees
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Brief Research Report
Case Report
Data Report
Editorial
FAIR² Data
FAIR² DATA Direct Submission
General Commentary
Hypothesis and Theory
Methods
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Article types
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
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